Acute lymphoblastic leukaemia Flashcards
1
Q
aetiopathogenesis
A
same as AML
2
Q
CF
A
children
-same as AML
3
Q
specific CF
A
Generalised lymphadenopathy
meningeal/testicular infiltration
4
Q
Haemoatolgy
A
same as AML
5
Q
Peripheral smear
A
> 20% lymphoblast
low granulocytes
normocytic normochromic anaemia
low platelets
morphology acc to subtypes (L1-L3)
6
Q
BM aspirate
A
> 20% lymphoblast
others same as AML
7
Q
cytochemical status
A
PAS +VE
8
Q
immunophenotyping
A
general:CD10
B CELL:CD 19,CD 20
T CELL:CD 2 ,5,7
9
Q
CYTOGENETIC studies
A
t(9:20)
t(8:14)
10
Q
prognosis
A
better
>85% children can be cured
5 year survival:69%
t(9:22)—> poor prognosis
11
Q
differentiate acute n chronic
A
n
