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PATHO B1 > chronic myeloid leukaemia (CML) > Flashcards

chronic myeloid leukaemia (CML) Flashcards

1
Q

AP

A

N

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2
Q

CF

A

anaemia
massive splenomegaly( dragging sensation on left side abd)
acute phase: similar CF to ACUTE LEUKAEMIA

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3
Q

DIAGNOSTIC TESTS

A

peripheral blood smear
BM studies
Cytogenetics:Karyotyping to detect P..ch
FISH analysis
RT-PCR

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4
Q

peripheral blood changes

A

-leucocytosis
-myelocytes,promyelocytes,myeloblast,normoblast,vand cells,mature polymorphonuclear granulocytes
-basophilia n eosinophilia
-normochromic anaemia
shift to the left: inc num of immature myeloid cells

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5
Q

bone marrow smear

A

hypercellular
marked reduction in fat spaces
granulopoiesis

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6
Q

prognosis

A

blast crisis—poor

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PATHO B1 (16 decks)

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