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PATHO B1 > Sickle cell disease > Flashcards

Sickle cell disease Flashcards

1
Q

peripheral blood

A

dec Hb
inc reticulocyte

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2
Q

peripheral smear

A

normocytic normochromic
anisopoikilocytosis
sickle cell,target cells,ovalocyte
WBC:mild inc
platelet:mild inc

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3
Q

sickling test

A
  • add reducing agent )2% sodium metabisulpite/sodium dithionite)
    Hbs:sickled and holly leaf appearance
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4
Q

Hb electrophoresis

A

HbS slow moving compared to others

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5
Q

other

A

HBF ESTIMATION
HPLC
PRENATSL DIAGNOSIS- detect point mutation tru aminomcentesis/chrionic villous b0ipsy–analsyse fetal DNA

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PATHO B1 (17 decks)

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