Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology > Tetracyclines > Flashcards

Tetracyclines Flashcards

1
Q

What are the first gen and second gen tetracyclines?

A

First gen: Tetracycline

Second gen: Doxycycline, Minocycline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is a glycylcycline?

A

Tigecycline is a minocycline derivative with better spectrum of activity and more ability to overcome bacterial resistance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Tetracyclines

Mechanism of Action

A

Reversibly bind bacterial 30S subunit

Prevent aminoacyl tRNA from binding and adding another AA to the chain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Tetracyclines are static or cidal?

A

Bacteriostatic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Tetracyclines

Mechanisms of Resistance

A

Efflux Pumps
Ribosomal Protection Proteins
Enzymatic Inactivation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Tetracycline
Spectrum of Activity
Gram Positive Aerobes

A 
MSSA
PSSP
Bacillus
Listeria
Nocardia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Tetracycline
Spectrum of Activity
Gram Negative Aerobes

A 
Burkholderia pseudomallei
Neisseria
Haemophilus
Campylobacter
Helicobacter
Vibrio
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Tetracycline
Spectrum of Activity
Anaerobes and Miscellaneous Bacteria

A 
Actinomyces
Legionella
Chlamydia
Mycoplasma
Ureaplasma
Rickettsia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Tigecycline
Spectrum of Activity
Gram Positive Aerobes

A

MRSA, MSSA

VRE, VSE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What conditions is tigecycline never used for?

A

Bacteremias and UTIs because it has a high distribution and can therefore not reach high blood concentrations

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What bacteria does tigecycline not have activity against?

A

Pseudomonas and Proteus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Tigecycline
Spectrum of Activity
Gram Negative Aerobes

A 
Acinetobacter baumannii
Citrobacter
E coli
Klebsiella
Serratia
Stenotrophomonas
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

How are most tetracyclines administered?

A

IV
Only doxycycline can be given oral or IV.
Absorbed best on an empty stomach

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What drugs impair absorption of tetracyclines?

A

Divalent and trivalent cations

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Tetracyclines

Distribution

A

Very broad distribution. Not well concentrated in the blood or bladder

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Tetracyclines Elimination

A

Tetracycline is renally eliminated.

Doxycycline and Tigecycline are excreted by mainly non-renal routes. Adjust tigecycline dosage in liver disease.

17
Q

Tetracycline Clinical Uses

A 
Respiratory Infections
STDs- Chlamydia, Syphilis, gonorrhea
Prophylaxis of malaria
Rocky Mountain Spotted Fever
Polymicrobial Infections (tigecycline)
Acne
SIADH
18
Q

Tetracycline

Adverse Effects

A

Nausea, vomiting
PHOTOSENSITIVITY
Reversible diabetes insipidus with outdated meds
Hepatic enzyme elevation

19
Q

Should tetracycline be used in pregnant women?

A

Never!

It is a Category D teratogen. Causes discoloration of permanent teeth and decreased bone growth in children.

Pharmacology (67 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions