Synaptic Transmission: Targets of Drug Action Flashcards

1
Q

Metyrosine

A

competitive inhibition of tyrosine hydroxylase

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2
Q

Reserpine

A

inhibits VMAT uptake of monoamines into vesicles

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3
Q

Bretylium

A

inhibit action potential generation and calcium dependent synaptic vesicle fusion

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4
Q

Cocaine

A

blocks monoamine reuptake

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5
Q

Amphetamine or Ephedrine

A

reverse monoamine reuptake transporters

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6
Q

Naloxone, Naltrexone

A

Non-peptide blockers of opioid receptors in CNS

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7
Q

SSRIs

A

Selective inhibition of serotonin reuptake transporter

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8
Q

ACE inhibitors, eg. lisinopril

A

Inhibits peptide cleavage of angiotensin I to angiotensin II

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9
Q

Phenylephrine

A

direct agonist of adrenergic receptor

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10
Q

MAO Inhibitors

A

blockade of cytoplasmic metabolism of monoamines

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11
Q

L-DOPA

A

precursor of dopamine, stimulates dopamine production

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12
Q

Carbidopa

A

Blocks L-DOPA conversion to dopamine, does not cross BBB, so protects peripheral adrenergic neurons from producing too much dopamine and NE

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13
Q

Tyramine

A

ingested in diet; competes with NE for transport into synaptic vesicle

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