Synaptic Transmission: Targets of Drug Action Flashcards
Metyrosine
competitive inhibition of tyrosine hydroxylase
Reserpine
inhibits VMAT uptake of monoamines into vesicles
Bretylium
inhibit action potential generation and calcium dependent synaptic vesicle fusion
Cocaine
blocks monoamine reuptake
Amphetamine or Ephedrine
reverse monoamine reuptake transporters
Naloxone, Naltrexone
Non-peptide blockers of opioid receptors in CNS
SSRIs
Selective inhibition of serotonin reuptake transporter
ACE inhibitors, eg. lisinopril
Inhibits peptide cleavage of angiotensin I to angiotensin II
Phenylephrine
direct agonist of adrenergic receptor
MAO Inhibitors
blockade of cytoplasmic metabolism of monoamines
L-DOPA
precursor of dopamine, stimulates dopamine production
Carbidopa
Blocks L-DOPA conversion to dopamine, does not cross BBB, so protects peripheral adrenergic neurons from producing too much dopamine and NE
Tyramine
ingested in diet; competes with NE for transport into synaptic vesicle