Pesky Hard to Remember Drugs Flashcards
Baclofen Physiological action
Direct agonist of the GABA-b receptor, which causes a decrease in Ca2+ influx at 1a afferents, causing less NT release. May be injected intrathecally
Baclofen indications
Spasmolytic drug used in spinal spasticity and MS
Baclofen Toxicity
Drowsiness and mental disturbances
Diazepam Indications
MS and spinal spasticity, flexor/extensor spasticity
Diazepam Physiological actions
Positive allosteric modulator of the GABA-a receptor, leading to increased Cl- influx and hyperpolarization of the membrane
Diazepam contraindications
Glaucoma! (Open angle or acute closed)
Diazepam toxicity
Drowsiness and sedation
Tizanidine physiological action
Alpha 2 adrenergic agonist, mostly in the CNS, inhibiting the release of more NT
Tizanidine indications
MS and spinal spasticity
Tiznidine toxicity
Drowsiness and HTN
Dantrolene Physiological action
Decreases Ca2+ release form the SR of skeletal muscle
Dantrolene Indications
MS, spinal spasticity, cerebral palsy, stroke, malignant hyperthermia
Dantrolene Toxicity
muscle weakness, HTN, sedation
What are the toxic effects of succinylcholine?
Hyperkalemia! Apnea Muscle pain (fasciculations) Increase in intraocular/intragastric pressure Bradycardia
Why do lidocaine and bupivicaine have different dosing requirements?
Bupivicaine has a higher degree of protein binding in the tissues, so it is sequestered more in the tissues and has a longer duration of action. You need a lower dose of bupivicaine than lidocaine (and lidocaine is often administered with epinephrine).