Pesky Hard to Remember Drugs Flashcards

1
Q

Baclofen Physiological action

A

Direct agonist of the GABA-b receptor, which causes a decrease in Ca2+ influx at 1a afferents, causing less NT release. May be injected intrathecally

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2
Q

Baclofen indications

A

Spasmolytic drug used in spinal spasticity and MS

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3
Q

Baclofen Toxicity

A

Drowsiness and mental disturbances

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4
Q

Diazepam Indications

A

MS and spinal spasticity, flexor/extensor spasticity

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5
Q

Diazepam Physiological actions

A

Positive allosteric modulator of the GABA-a receptor, leading to increased Cl- influx and hyperpolarization of the membrane

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6
Q

Diazepam contraindications

A

Glaucoma! (Open angle or acute closed)

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7
Q

Diazepam toxicity

A

Drowsiness and sedation

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8
Q

Tizanidine physiological action

A

Alpha 2 adrenergic agonist, mostly in the CNS, inhibiting the release of more NT

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9
Q

Tizanidine indications

A

MS and spinal spasticity

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10
Q

Tiznidine toxicity

A

Drowsiness and HTN

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11
Q

Dantrolene Physiological action

A

Decreases Ca2+ release form the SR of skeletal muscle

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12
Q

Dantrolene Indications

A

MS, spinal spasticity, cerebral palsy, stroke, malignant hyperthermia

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13
Q

Dantrolene Toxicity

A

muscle weakness, HTN, sedation

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14
Q

What are the toxic effects of succinylcholine?

A
Hyperkalemia!
Apnea
Muscle pain (fasciculations)
Increase in intraocular/intragastric pressure
Bradycardia
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15
Q

Why do lidocaine and bupivicaine have different dosing requirements?

A

Bupivicaine has a higher degree of protein binding in the tissues, so it is sequestered more in the tissues and has a longer duration of action. You need a lower dose of bupivicaine than lidocaine (and lidocaine is often administered with epinephrine).

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