Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology > Adrenergic Antagonists > Flashcards

Adrenergic Antagonists Flashcards

1
Q

What are the three non selective Beta blockers?

A

Propranolol
Timolol
Nadolol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the two cardioselective Beta blockers?

A

Atenolol

Metoprolol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is a partial agonist of B1 and B2 receptors?

A

Pindolol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

How do all beta blockers affect the heart?

A

They decrease heart rate and force of contraction. (Note: partial agonist pindolol’s bradycardic response is limited).

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

How do nonselective Beta blockers affect peripheral resistance?

A

They block B2 receptors, so they decrease vasodilation and increase peripheral resistance. There is unopposed vasoconstriction by A1 receptors.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

How do cardioselective Beta blockers affect peripheral resistance?

A

They have no effect because they do not block B2 receptors.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How does partial agonist pindolol affect peripheral resistance?

A

Slight decrease due to partial B2 activation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

How do all beta blockers affect renin release?

A

They all decrease renin release because they all decrease B1 activation.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

How do nonselective Beta blockers affect bronchioles?

A

They cause bronchoconstriction due to their blocking of B2 receptors. You should NEVER give a beta blocker to an asthmatic patient!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

How do cardioselective beta blockers affect bronchioles?

A

Little bronchoconstriction because cardioselective beta blockers only block B1 receptors. Still not recommended in asthmatics.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

How does partial agonist pindolol affect bronchioles?

A

Some bronchodilation, but asthmatics have a reduced capacity to dilate bronchioles.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

How do nonselective beta blockers affect glucose metabolism?

A

Reduced hyperglycemic response ot epinephrine. Use caution with these drugs in diabetics because they can mask symptoms of hypoglycemia.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

How to cardioselective beta blockers affect glucose metabolism?

A

Little effect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

How does partial agonist pindolol affect glucose metabolism?

A

Reduced response to epinephrine because partial agonist activity is not as potent as endogenously released epinephrine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are the physiological effects of non selective beta blockers? (Propranalol, Nadolol, Timolol)

A 
Decreased HR
Decreased renin release
Decreased contractility
Reduced sympathetic activation
Inhibition of aqueous humor production
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are the indications of nonselective beta blocker usage?

A 
Hypertension
Angina
Glaucoma
Early-moderate heart failure
Arrhythmia
Thyrotoxicosis
Anxiety
17
Q

Toxicity of nonselective beta blockers?

A

Bronchospasm
Mask symptoms of hypoglycemia
Bradycardia

18
Q

Contraindications of nonselective beta blockers?

A

Bronchospasm during asthma
Sinus bradycardia
2nd and 3rd degree heart block
Cardiogenic Shock

19
Q

Cardioselective Beta blockers physiological effects?

A

Decrease HR
Decrease contractility
Decrease renin release
Decrease sympathetic activation

20
Q

Cardioselective Beta blockers toxicity?

A

Hypotension

Bradycardia

21
Q

Cardioselective Beta blockers Indications?

A

Hypertension
Angina
Arrhythmia

22
Q

Cardioselective Beta blockers Contraindications?

A

Sinus bradycardia
2nd and 3rd degree heart block
Cardiogenic shock
Severe heart failure

23
Q

Partial agonist pindolol physiological effects?

A

Decrease BP
Decrease contractility
Decrease renin release
Decreased sympathetic activation

24
Q

Partial agonist pindolol indications?

A

Hypertension

25
Q

Partial agonist pindolol toxicity?

A

Hypotension
Dizziness
Depression
Insomnia

26
Q

Partial agonist pindolol Contraindications?

A

Sinus bradycardia
2nd and 3rd degree heart block
Cardiogenic Shock
Severe heart failure

27
Q

What are the nonselective alpha blockers? Which ones are reversible or irreversible?

A

Phentolamine (reversible)

Phenoxybenzamine (irreversible)

28
Q

Phentolamine and Phenoxybenzamine physiological effects?

A

Decreased BP

Increased chronotropy and inotropy (large increase in HR)

29
Q

Phentolamine and Phenoxybenzamine Indications?

A

Hypertension associated with pheochromocytoma

Vasoconstrictor-induced extravasation

30
Q

Phentolamine and Phenoxybenzamine Toxicity?

A

Prolonged hypotension

Reflex tachycardia

31
Q

What are the selective alpha-1 adrenergic blockers?

A

Prazosin
Doxazosin
Terazosin

32
Q

Selective alpha-1 antagonist physiological effects?

A

Inhibit vasoconstriction

Prostate smooth muscle relaxation

33
Q

Selective alpha-1 antagonist Indications?

A

Hypertension

Benign prostatic hyperplasia

34
Q

Selective alpha-1 antagonist toxicity?

A

Orthostatic hypotension
Syncope
(These drugs are not prescribed to the elderly because they may increase risk of falls)

Pharmacology (67 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions