Oxazolidinones

Question 1

What are the two oxazolidinones?

Answer 1

Linezolid

Tedizolid

Question 2

Linezolid Mechanism of Action

Static or Cidal?

Answer 2

Binds the 50S subunit of bacterial ribosomes, preventing formation of the 70S ribosome when combining with the 30S subunit

BACTERIOSTATIC

Question 3

Linezolid Mechanisms of Resistance

Answer 3

Alterations in ribosomal binding sites (rare)

Question 4

Linezolid Spectrum of Activity

Answer 4

Gram Positives
MSSA, MRSA, coagulase negative Staph
Strep pneumoniae, PRSP
Enterococcus (including VRE)

NOT ACTIVE against C diff

Question 5

Linezolid Absorption

Answer 5

IV or Oral
100% bioavailability
CSF Penetration is about 30%

Question 6

Linezolid Elimination

Answer 6

Has Renal and nonrenal elimination

DO NOT need to adjust dosing for renal insufficiency

Question 7

Linezolid Clinical Uses

Answer 7

Serious/complicated infections caused by resistant Gram Positive bacteria

• VRE bacteremia
• Nosocomial pneumonia due to MRSA
• serious infections due to MRSA
• Use Linezolid when you cannot use vancomycin

Question 8

Linezolid Drug Interactions

Answer 8

DO NOT use linezolid with SSRIs or MAOIs. Could cause serotonin syndrome.

Could enhance pressor response to dopamine or epinephrine

Question 9

Linezolid Adverse Effects

Answer 9

Lactic acidosis
Peripheral Neuropathy
Thrombocytopenia
Anemia

Question 10

What is the advantage for using tedizolid over linezolid?

Answer 10

No SSRI interactions!