Test Two membrane structure Flashcards
function of membrane
lipid bilayer of molecules, transport barrier, contains transport channels, flexible, expandable, and repairable
the lipid bilayer contains
phospholipids
what is amphipathic
membrane layer contains a polar and non polar portion
how is the lipid bilayer favorable
forms a ball to increase entropy
how is the lipid bilayer fluid
lipid molecules shift within the membrane, rotating and changing places
fluidity of the lipid bilayer depends upon
composition of lipid bilayer, packing of lipids by the length of the hydrocarbon tail and degree of saturation, environmental temperature
longer hydrocarbon tails mean what about fluidity
less fluidity
degree of saturation talks about what
number of hydrogen molecules around a carbon
saturated tails are
single bonds, contain more hydrogens and less fluid
unsaturated tails are
double bonds, fewer hydrogens, more fluidity, kinked
how does environmental temperature affect fluidity in lipid bilayer
affects length and saturation of hydrocarbon tails
what molecule prevents fluidity and enhances permeability barrier
cholesterol
what is the function of fluidity
cellular interactions, movement of proteins and lipids, fusion and division of membranes
what are the predominant phospholipids
phosphoatidylcholine, phosphoatidylethanolamine, phosphatidylserine, sphingomyelin
what are scramblases
enzyme that causes random movement of lipids from side to another to help equal out growth of bilayer
what are flippases
enzymes that cause specific movement of lipids
membrane synthesis occurs where
in the endoplasmic reticulum, lipids in SER and proteins in RER
how are glycolipids synthesized
so they face outside the cell
what is involved with glycolipid synthesis
transporting vesicles, no flippases
what do inositolphospholipids do
play a role in direction they are positioned
function of membrane proteins
membrane transport, anchors for stability, cell signaling receptors, enzymes for reactions
what are transmembrane proteins
located through membrane, hydrophillic outside and hydrophobic inside
what are membrane associated proteins
located in the cytosol only on half the bilayer,
structure of membrane associated proteins
amphipathic alpha helix on surface of membrane
where are lipid linked proteins located
outside of the membrane except for the lipid group covalently anchored to membrane
what is the anchored lipid in lipid linked proteins
glycosylphosphatidylinositol (GPI)
how do protein attached proteins work
interact to non covalently with a membrane bound proteins and associates them with plasma membrane
which membrane proteins are intergral
transmembrane, monolayer associated, and lipid linked
which membrane proteins are peripheral
protein attached
how to isolate integral membrane proteins
destroy membrane with detergent to gain access to protein
how to isolate peripheral membrane proteins
membrane intact but remove protein with pH change
Describe transmembrane proteins with alpha helix
Span membrane, contain hydrophobic on outside and hydrophilic on inside
Single pass proteins use how many helices
One
Single alpha helices for single pass proteins are used for what
Cell signaling and receptors
Multi pass proteins use how many alpha helices
Several
Multi pass proteins with several alpha helices are used for
Pores
Transmembrane proteins using beta barrels are used for what
Structure and proteins
Cell membrane is strengthened by
Protein-attached proteins
What forms the cell cortex
Fibrous proteins such as spectrin
Purpose of spectrin
Strengthen the membrane on the cytosolic side and contains multiple binding sites
What is an example of a strong cell cortex
RBC, has strong cortex to create its shape
What is a way to restrict movement of membrane proteins
Membrane domains
What are some membrane domains
Tethers and diffusion barriers
What is glycocalyx
The cell coat
What are the carbohydrates on the cell surface
Glycoproteins and proteoglycans
Glycoproteins attach to what
Oligosaccharides
Are glycoproteins short or long
Short
Proteoglycans attach to what
Polysaccharides
Are proteoglycans short or long
Long
Function of carbohydrates on the cell surface
Protection from mechanical or chemical damage, lubrication to allow to slip into small or tight spaces, interaction with other cells, recognition