Test Four Tissues And Cancer Flashcards
Tissues form from
Cells joining together and extracellular matrix
Tissue maintenance consists of
Renewal and repair
What are cellulose fibers
Long fibers of polysaccharides
Cellulose fibers are formed by
Enzymes in plasma membrane interweaving into cell surface
Cellulose microfibrils guided by
Microtubules
Animal connective tissue
Tendons, bone and cartilage
Structure of collagen
Super helix, collagen fibrils that come together to make fibers
What makes collagen
Fibroblasts and osteoblasts
What is secreted by collagen fibrils with collagenase
Procollagen
Example of defect in collagenase
Ehlers Danlos Syndrome (stretchy skin)
How is collagen arranged
Secreted from cell and is put into place
What other components are in collagen
Fibronectin and integrins
Function of fibronectin in collagen
Grab collagen and bind to cell
Function of integrins in collagen
Bind to fibronectin and connect to cell
Function of proteoglycans
Link to GACs and resist compression, fills spaces and controls rate of water passage
Function of epi
Protective barrier, absorption, secretion and communication
Epi consists of
Apical and basal surface
Apical surface function
Absorbing, secreting and communication
Function of basal surface
Bind cells, anchors
Function of intestinal epi
Protective layer
Function of absorptive cells
Nutrients
Function of goblet cells
Mucous
Function of tight junctions
Tight seal, mechanical strength and communication
What forms tight junctions
Claudins and occludins
Adherin junctions are held together by
Actin and form adhesion belt
Desmosome junctions are
Linking intermediate filaments through Cadheirns, link keratin together
Hemidesmosomes are
Link with intermediate filaments with integrins by anchoring to basal membrane
Cadherins are
Adaptors in between cells
Adherin junctions found where
Near top
Gap junctions have narrow gaps called
Connexons
Can gap junctions open and close
Yes
Function of gap junctions
Communication
Cell to cell adhesion uses
Desmosomes and actin bundles
Cell communication occurs
With cells around and gap junctions
Are nerve cells replaced
Nope
Intestinal epi replaced when
Every couple of days
Bone cells replaced
6 years
RBCs replaced every
120 days
Skin replaced every
2 months
Each stem cell can either
Differentiate or remain a daughter stem cell
What are hematopoietic stem cells
Potential cells to be anything
What cells can we turn into stem cells
Fat and bone cells
Causes of mutation
Inheritance, ionizing radiation, mutagens/ carcinogens, viruses
Example of preventable cancer
HPV and cervical
Somatic mutation
Cancer in mature body
Germ line mutation
Unborn situation
Damage mutation
Ionizing radiation, mutagen
Cancer properties
Enhanced cell proliferation, less of a response, no cell death, genetically unstable, invasive
Oncogenes
Genes that are mutated with dangerous result
Proto-oncogenes
Normal genes with potential
Tumor suppressor genes
Cancer critical genes
What causes colorectal cancer
Gene mutation and somatic mutation
What gene is missing in colorectal cancer
APC tumor suppressor gene
Treatments for cancer
Surgery, radioactive therapy, DNA destroying chemotherapy, choking blood supply, targeting cancer products, immunotherapy