test 7 thiazolidinediones

Question 1

Thiazolidinediones (TZDs, glitazones) are

Answer 1

• insulin sensitizers

Question 2

Thiazolidinediones (TZDs, glitazones) mechanism of action

Answer 2

• TZDs lower insulin resistance by acting as agonists for peroxisome proliferator-activated receptor (PPARγ), a nuclear hormone receptor.
• Activation of PPARγ stimulates the expression of insulin responsive genes.
• Effects mimic insulin; increases insulin sensitivity in liver, fat, and muscle.
• TZDs also decrease cholesterol and triglycerides.