test 5 local anesthetics

Question 1

What do Local Anesthetics do

Answer 1

• Block nerve conduction of sensory impulses
  * Block Na channels in CNS which prevents action potential propagation
  * High doses can block motor impulses
• Sensation cannot be transmitted to the brain
• Cause vasodilation
  * Often given with epinephrine to vasoconstrict area and extend duration of action
  * Duration determined by redistribution

Question 2

Local Anesthetics Delivery options

Answer 2

• Topical
• Infiltration
• Peripheral nerve blocks
• Neuraxial blocks (spinal, epidural, caudal)