test 7 Sulfonylureas and Glinides

Question 1

Sulfonylureas and Glinides are

Answer 1

• These agents are insulin secretagogues; they promote insulin release.

Question 2

Sulfonylureas and Glinides mechanism of action

Answer 2

• These drugs block ATP-sensitive K+ channels, resulting in depolarization and calcium influx in β-cells. Increased [Ca]i stimulates insulin release.
• Also decreases hepatic glucose production and improves insulin sensitivity.

Question 3

Sulfonylureas and Glinides duration of action comparison

Answer 3

• Sulfonylureas: Duration of action ranges from 12 to 24 hours.
• Glinides: Faster onset and shorter duration of action than the sulfonylureas