test #31 4.20 Flashcards
1
Q
posteroinferior wall of left ventricle supplied by.. infarct on ECG?
A
posterior descending branch of RCA.
ST elevations in leads II, III, aVF
2
Q
transmural ischemia of interventricular septum on EKG?
A
ST elevation in leads V1 V2
3
Q
transmural ischemia of anterior left ventricular wall on EKG?
A
ST elevation in V3 V4
4
Q
occlusion of proximal LAD infarcts.. causes on EKG?
A
infarts anteroseptal transmural ischemia. ST elevations in V1-V4
5
Q
anterolateral infarct of left ventricle on EKG?
A
LCX or LAD – V4-V6
6
Q
lateral wall of left ventricle infarct on EKG?
A
I, aVL & V5-V6
7
Q
which segment of intestine is always involve w/ hirschsprung? why?
A
rectum, bc ganglion cells of submucosa & myenteric plexi travels caudally.
aganglionic segment -> constricted bc cannot relax
8
Q
torsades
A
form of ventricular tachycardia.
polymorphic QRS complexes of varying amplitudes and cycle length.
give appearance that the tip of QRS is twisting around ECG baseline.
always associated w/ underlying prolonged QT
9
Q
prolonged QT caused by..
A
class IA and III antiarrhythmics
(not amiodarone)
phenothiazines
TCAs
10
Q
lidocaine fxn by..
A
blocking Na+ channels
11
Q
penicillins are structurally stimilar to
A
terminal d-ala-d-ala of peptidoglycan molecule
blocks transpeptidase
12
Q
N-acetylmuramic acid and N-acetylglucosamine are
A
peptidoglycan precursor molesules of cell wall in bacteria
13
Q
sulfonamide antibiotic mechanism? trimethoprim
A
sulfonamides: compete w/ PABA (paraaminobenzoic acid) for incorporation into folic acid..
trimethoprim: block dihydrofolate reductase
14
Q
staph epidermidis infxn?
rx:
A
major cause of infection in pts w/ indwelling catheters or implanted foreign bodies.
produces biofilm (polysaccharide slime) allows adhesion.
diagnosis: recover from mult cultures (can be contaminant)
rx: initial aggressive. vancomycin w/ rifampin or gentamycin or both.
can be resistant to methicillin
15
Q
rx for staph epidermidis bactermia. if not..?
A
aggressive! vancomycin + rifampin + gentamycin
w/o rx: indolent endocarditis after valve replacement. intracardiac abscess formation, dehiscence of prosthetic valve, septic embolization
16
Q
AML blasts will stain positive for
A
peroxidase (since Aur rods have MPO)
17
Q
TdT in lymphocytes
A
terminal deoxynucleotidyl tranferase
add nucleotides to V D J regions of Ab gene for diversity.
mature of immature B and T cells
18
Q
hairy cell leukemia stains. what type of cells are they?
A
TRAP (tartare resistant acid phosphatase)
B-cells! CD20+
splenomegaly, fatigue, pancytopenia
19
Q
glomus body & glomus tumor
A
small, encapsulated neurovascular organ. temp regulation
in dermis of nail bed, pads of fingers & toes, ears
afferent arteriole –> richly innervated, muscular arteriovenous anastomosis –> efferent vein.
role:
COLD: shunt blood AWAY from skin surface: prevent heat loss
HEAT: direct blood TO skin, facilitate dissipation of heat.
form PAINFUL tumors under fingernail. arises from modified smooth muscle cells.
20
Q
skin presentation of histiocytosis
A
erythematous papules, nodules, and/or scaling plaques
21
Q
electrolyte presentation of primary adrenal insufficiency (Na, K, Cl, HCO3)
A
low Na
high K
low Cl
low HCO3
22
Q
primary adrenal insufficiency vs. secondary / tertiary (i.e. pituitary / hypothal)
A
primary – loose aldosterone, cortisol, and androgens
secondary – loose cortisol only. aldosterone triggered by renin / angiotensin system!
23
Q
Na+ in hyperaldosterone?
A
initial increase, but aldosterone loss –> intravascular hypervolemia –> ANP –> diuresis & compensatory Na+ loss
24
Q
why is supraspinatus injury most common of rotator cuff?
A
repeated impingement trauma between humeral head & acromion
abbductor
25
subacromial bursa location
under both acromion/clavicle & tendon of deltoid muscle.
sits on top of supraspinatus
26
why no hep C vaccine // why prone to chronic infection
variety in antigenic structure of HCV envelope proteins
1. multiple genotypes & subgenotypes
2. hypervariable region of envelope glycoprotein -- prone to frequent mutation
3. no proofreading 3-5' exonuclease
constantly emerging mutant strains &much variety in a single person at one time
27
positive trendelenburg sign
hip dips to unaffected side when standing on affected sign (failure of gluteus medius/minimus to pull pelvis down and abduct thigh) --> superior gluteal n.
28
sciatic n. innervates all knee flexors except..
biceps femoris
29
Tzanck prep
Wright-Giemsa stain on epithelial cells scraped from ulcer base.
see multinucleated giant cells w/ some intranuclear inclusions -- HSV & VZV
30
primary vs. reactivation HSV-1 infxn
recurrent:
- usu one side
- much less extensive area involved (limited)
- favor skin around mucosal orifice (lips & nose)
- bilateral
- larger area
- gingivostomatitis: gums & oral mucosa
31
primary vs. reactivation of VZV infxn
reactivation won't cross midline either
32
latency means..
full viral genome persists in host cells, but infectious virons cannot be recovered from those cells that harbour the virus.
33
slow virus infection
prolonged incubation period, months to years. virus persistently infects host & multiplies before gradually causes clinically apparent disease.
predominantly progressive, degenerative disorder of CNS -- SSPE, PML
34
S3 sound
early in diastole. sudden deceleration of entering blood column as ventricle reaches its elastic limit
reverberation of blood between ventricle walls. low frequency
1. forceful, rapid filling of a ventricle w/ normal or elevated compliance
2. normal, or even decreased filling rates when compliance is low
3. blood flowing into an overfilled ventricle w/ high end-systolic volume
35
murmur associated w/ HCM
dynamic LVOT -- mitral regurgitation -- systolic. or 'aortic stenosis' like??
36
pattern of drug administration for nitrates?
nitrate free interval every day. rapid tolerance
due to decreased vascular sensitivity & increased sensitivity to vasoconstriction
37
MAO inhibitors (phenelzine) fxn by..
IRREVERSIBLY bind. takes 2 wks post discontinuation to regenerate enzyme
wait before giving SSRI
38
SSRI + MAOi =
serotonin syndrome. wait 2 wks after discontinuing MAOi before giving SSRI
39
drug of choice for paroxysmal supraventricular tachycardia?
adenosine -- open K+ channels, hyperpolarize AV node.
| acts in manner similar to muscarinic cholinergics
40
side effects of adenosine for PSVT?
flushing, chest burning (bronchospasm), hypotension, high grade AV block
41
side effects of amiodarone
blue-grey skin discoloration, photodermatitis, pulmonary fibrosis, hypo/hyperthyroidism
42
lidocaine side effects/toxicity
neurologic symptoms usu
43
procainamide toxicity
usu drug-induced lupus syndrome
44
verapamil side effects
gingival hyperplasia and constipation
45
digoxin/digitalis side effects / toxicity
fatigue, blurry vision, changes in colour perception, nausea & vomiting, diarrhea, abdominal pain, confusion, delirium
46
drug used for chemical stress test?
adenosine! causes bronchospasm, flushing, high grade block!
47
vomit pathway
proprionylCoA --> methymalonylCoA
(propionylCoA carboxylase + biotin)
methylmalonylCoA --> succinylCoA
methylmalonylCoA mutase
48
malonyl CoA comes from..
acetylCoA + acetylCoA carboxylase
49
methylmalonyl CoA comes from..
propionylCoA + propionylCoA carboxylase
50
hydrolysis in urea cycle
arginine to ornithine via arginase
51
transamination
converts alpha-ketoacids to amino acids (via transfer of amino group from one amino acid to alpha-keto acid)
usu requires B6
52
methylmalonic acidemia
defet in isomerization rxn. transforms methylmalonyl CoA to succinyl COA -- TCA
53
parvovirus infxn in adult:
arthritis involving proximal interphalangeal, metacarpal knee, and ankle
usu symmetric (like RA) but spontaneously resolves (unlike RA)
54
hyaline membranes in ARDS
alveolocapillary membrane leakage. fibrin exudate and plasma protein-rich edema fluid mixed w/ cytoplasmic and lipid remnants of necrotic epithelial cells.
exudate-like. not transudate.
55
smell is from..
apocrine glands
56
apocrine glands
dermis / subcutaneous fat of breast areolae, axillae, genital.
membrane bound vesicles "sweat" into hair follicles. rather than directly to skin.
innervated by adrenergic fibers of sympathetic nervous system. not fxn until puberty.
women -- cyclical changes secondary to hormonal influence w/ menstrual cycle.
usu odorless when secreted. malodorous secondary to activity of commensal bacteria in skin.
57
holocrine glands
associated w/ SEBACEOUS glands. discharge of entire cell undergo breakdown to release secretory product & meibomian glands in eye
58
eccrine (merocrine)
skin throughout body. except lips and glans penis.
merocrine glands secret watery fluid rich in Na and Cl "sweat" directly to skin
59
mammary glands (lactation)
modified sweat glands. apocrine secretion.
60
aldosterone functions by..
binding to intracellular receptor and altering gene expression
(1) more Na/K pumps
(2) ENaC on principal cells
(3) increase K+ secretion from principal cells
(4) increase H+ secretion from intercalated cells
61
which chemical increases urea transport in collecting ducts
ADH
62
inheritance of phenylketonuria?
autosomal recessive. mental retardation, eczema, mousy musty body odor
63
ritodrine and terbutaline
b2 agonist. tocolysis. relaxes uterus. defer premature labor
64
inheritance of glucose 6 phosphate dehydrogenase
x-linked recessive
65
MOST structural abnormalities are inherited as..
```
autosomal dominant
(i.e. hereditary spherocytosis)
```
66
MOST enzyme deficiencies inherited as..
autosomal recessive
67
X-linked dominant? example
100% risk to female offspring of an affected male.
vitamin-D-resistant rickets
68
when does mismatch repair (i.e. that mutated in lynch: MSH2 and MLH1) function
shortly after daughter strands synthesized.
69
DNA deaminating agents. repair?
nitrous acid.
base pair excision repair: glycosylase detect, create an empty sugar-phosphate residue (apurinic site)
70
how does alcohol cause pancreatitis
induces pancreatic secretions w/ high protein concentration and low fluid content -- prone to ppt.
also causes spasm of sphincter of Oddi -- direct toxic effect on acinar cells
71
main causes of acute pancreatitis (2)
1. gallstones
| 2. alcohol abuse!
72
alcohol abuse leads to what hematological abnormality
macrocytosis (MCV) secondary to...
(1) poor nutrition: folate / b12
(2) direct toxicity of alcohol on bone marrow
73
3 indicators of chronic alcohol abuse
(1) macrocytosis (RBC)
(2) AST:ALT ratio > 2
(3) elevated gamma-glutamyltransferase (GGT)
macrocytosis can occur independently of folate or cobalamin deficiency
74
chediak-higashi
phagocyte dysfunction:
BALIN
autosomal recessive
defect in LYST -- lysosomal regulator gene. MT dysfunction in phagolysome-lysosome function.
- bleeding and bruising (platelet deficiency)
- albinism (partial oculocutaneous albinism)
- leukopenia
- infxn w/ staph strep peripheral
- neuropathy
75
wiskot aldrich
B and T cel disorder
mutation in WAS
X-linked recessive
T cells unable to reorganize actin.
B cells can't anchor membrane bound receptors well
WATER
wiskot-aldrich
thrombocytopenic purpura
eczema
recurrent infection
low to normal IgG and IgM
high IgE and IgA
fewer and smaller platelets
increased risk of non-hodgkin's lymphoma
76
immunodeficiency with partial oculocutaneous albinism and neurological defects (i.e. nystagmus)
chediak-higashi (defective neutrophil phagolysosome function)
77
side effects of lithium
LMNOP
```
lithium
movement (tremor)
nephrogenic diabetes insipidus
hypOthyroidism
pregnancy -- ebstein's anomaly
```
monitor BUN/creatinine and TSH
78
clozapine atypical antipsychotic can cause
agranulocytosis & seizures
79
risperidone can cause..
increase prolactin.
galactorrhea and amenorrhea
80
trazodone side effects
painful erection (priapism), orthostatic hypotension, sedaition
81
olanzipine/clozapine side effect
weight gain
82
ziprasidone side effect
prolong QT
83
atypical antipsychotic with least side effect
aripripazole
84
presentation of polycythemia vera
plethoric face, splenomegaly.
increase incidence of..
1. peptic ulcerative (altered blood viscosity)
2. itching (histamine release from basophils)
3. gouty arthritis (increased cell turnover)
85
examples of JAK STAT signalling
ERO
86
describe JAK STAT signalling
nonreceptor tyrosine kinase.
ligand binds --> JAK comes and phosphorylates. attracts STAT, which is phosphorylated --> then goes to nucleus for effect
87
examples of RTK activity
insulin, IGF-1, EGF
88
li-fraumeni syndrome associated w/ which cancers
- sarcomas and tumor of breast
- brain
- adrenal cortex
89
photosensitivty in porphyria due to
formation of porphyrin-mediated superoxide free radicals from oxygen upon sunlight exposure
90
where does H. pylori like living in the stomach?
antrum: in prepyloric area, where there are few acid-secretory parietal cells.
will cause gastric metaplasia of duodenum (due to increased acid secretion), and will THEN colonize duodenum
91
where can H. pylori live?
ONLY in areas of gastric metaplasia!
can't live in normal duodenum
92
myocardial biopsy with interstitial collection of mononuclear inflammatory cells * scattered multinucleated giant cells, surrounded by fibrosis?
interstitial myocardial granulomas: aschoff bodies)
acute rheumatic carditis.
plump macrophages w/ abundant cytoplasm & central, round-to-ovoid nuclei w/ central, slender, chromatin ribbons -- Anitschkow cells "caterpillar".
Aschoff giant cells: when larger macrophages become multinucleated.
can be found in any 3 layers of heart. later replaced by fibrous scar tissue.
preceeded by episode of group A strep 10 days to 6 wks earlier
93
predominantly lymphocytic interstitial inflammatory infiltrate w/ focal necrosis of myocytes adjacent to inflammatory cells
viral myocarditis
94
interstitial inflammatory infiltrate of mononuclear inflammatory cells & eosinophils in heart
hypersensitivty myocarditis
95
diptheric myocarditis
circualting toxin produced by primary focus of infxn in upper aerodigestive tract (tonsilopharyngitis)
pleomorphic interstitial infiltrate of macrophages w/o distinct Ascoff-body type granulomas
96
distension of individual myofibers w/ intracellular trypanosomes in heart?
chagas disease, trypanosoma cruzi
97
most common cause of end state renal failure in US
diabetic nephropathy
98
kidney disease w/ hyperuricemia?
monosodium urate crystal ppt in medullary interstitium --> fibrosis and foreign-body granulomas (gouty nephropathy).
can result in chronic renal failure.
microscopically -- negatively birefringent under polarized light
99
psychogenic erectile dysfunction
usually sudden & have spontaneous morning erections (integrity of neurologic / vascular disease)
100
what sexual features decrease w/ age
longer refractory period, take longer to achieve erection
sexual desire does not fall
101
most common mediations causing impotence
SSRI and sympathetic blockers (clonidine, methyldopa, beta blockers)
102
signs of irreversible injury in heart
mitochondrial vaculolization
appearance of vaculoes and phospholipid-containing amorphous densities WITHIN mitochondria
implies permanent inability to generate ATP via oxidative phosphorylation.
[simple mito swelling = reversible]
103
myofibril relaxation results from..
reversible injury:
within 30min of injury.
corresponds w/ intracellular ATP depletion & lactate accumulation due to anaerobic glycolysis
104
disaggregation of polysomes is a sign of
dissociation of rRNA from mRNA.
reversible injury
105
disaggregation of granular and fibrillar elements of nucleus is a sign of..
clumping of nuclear chromatic is a sign of..
both: reversible cell injury.
perhaps due to change in pH
106
glycogen loss in myocardium is a sign of...
reversible cell injury.
less mito ATP -- use glycogen
glycogen stores can be depleted within 30 min of severe ischemia
107
triglyceride droplet accumulation in cells is a sign of..
reversible injury, esp in hepatocytes. also in striated muscle injury and renal cells.
results from decreased synthesis of intracellular proteins within cell injury.
hepatocytes: decrease production of lipid acceptor proteins --> prevents incorporation of lipid into lipoproteins --> accumulate in cell
108
vascular dementia vs. alzheimer's
multiple lacunar infarcts: STEP-WISE decline in cognition
alzheimer's: gradual decline
109
which cells in testes are temperature sensitive
sertoli cells must more temperature sensitive (seminiferous tubules in general)
110
which hormone is decreased in cryptoorchidism?
inhibin --
sertoli cells are very temperature sensitive and prone to heat-induced damage.
seminferous tubules become atrophic and hyalinized --> low sperm count.
leydig cells are NOT very temperature sensitive --> secondary sexual characteristics develop just fine.
111
broadly speaking, tests that evaluate hepatobilary disease assess what 3 things
(1) liver functionality: PTT, bilirubin, albumin, cholesterol
(2) structural integrity & cellular intactness of liver (transaminase)
(3) bililary tract (ALP, gamma-glutamyl transferase)
112
alkaline phosphatase
group of enzymes associated w/ metabolic activity in a number of tissues (liver, bone, intestine, kidney, placenta, leukocytes, some neoplasms)
primary source: BONE & LIVER
3x elevation = nonspecific finding for many liver disease.
113
GGT (gamma glutamyl transpeptidase)
enzyme primarily in hepatocytes and biliary epithelia.
can be found in various extrahepatic tissues (kidney, spleen, pancreas, heart, lung, and brain)
NOT present much in bone.
therefore, useful to determine whether ALP is of hepatic or bony origin
114
determine if ALP is of bony / hepatic origin
look at GGT
115
lactate dehydrogenase measures
nonspecific test, evaluation of tissue injury or death
116
CML vs. leukomoid reaction
CML: low leukocyte alkaline phosphatase score
117
CD14
macrophage and monocyte.
receptor for LPS (activates macrophage)
118
atypical reactive T cells in EBV are..
CD8+ T cells -- ready to attack EBV infected B cells
119
how does EBV get into B cells
CD21
