test #28 4.19 Flashcards
examples of delayed-type hypersensitivity reactions
(1) contact dermatitis
(2) granulomatous inflammation
(3) tuberculin skin test
(4) candida extract skin reaction
delayed-type HSR mediated by..
T-lymphocytes (not Ab or complement).
reaction takes 1-2 days, bc antigen taken up by dendritic cells, present to CD4+ cells on MHC II.
Th1 cells secrete IFN-gamma, recruit & stimulate macrophages –> monocytic infiltrate.
[also occurs when ‘walling off’ TV
increased WBC post-corticosteroids
falsely elevated. due to demargination (release from vascular walls) of cells
2 disorders of mast cells
urticaria pigmentosum. systemic mastocytosis
what two factors drive angiogenesis
VEGF and FGF
- vascular ENDOTHELIAL growth factor
- fibroblast growth factor
VEGF: angiogenesis in variety of tissues: normal, chronically inflammed, healing, neoplastic. increases endothelial cell motility and proliferation –> new capillaries.
FGF-2: made by many cells. significantly involved in (1) promotion of endothelial cell proliferation, migration, and differentiation. also: impt in (2) embryogenesis (stimulating angioblast production)
[FGF: angiogenesis, embryonic develoment, hematopoiesis, wound repair]
somatomedin C
IGF-1
synthesized by growth-hormone influenced hepatocytes. stimulate cell growth and multiplication.
barrier to angiogenesis
laminin in basement membranes
non-viral-dependent nucleotides analogues
cidofovir (activated by cellular kinase) & tenofovir
rx for thymidine kinase-deficient (acyclovir-resistant) varicella?
fosacarnet: (PYROPHOSPHATE analog viral DNA polymerase inhibitor)
cidofovir: broad spectrum NUCLEOTIDE. analogue of cytidine monophosphate (activated by CELLULAR kinase)
factitious disorder vs. malingering
both CONSCIOUSLY creates symptoms.
factitious: for 1’ gain (sick role/medical attn)
malingering: for 2’ gain (avoid work, compensation)
munchausen syndrome
chronic factitious disorder
conversion disorder
unconscious; somatic.
post-stressor.
sudden neurological symptoms (loss of sensory/motor) with NO physical evidence.
somatic disorder vs. factitious & malingering
somatic disorder syndromes (i.e. conversion, hypochondriaisis, somatization) are UNCONSCIOUS
factitious & malingering: CONSCIOUS
somatization disorder (vs. conversion disorder)
somatoform disorder, several symptoms
usu begins <30 y/o. impact social/occupation.
4 pain
2 GI
1 sexual
1 neuro
with no physical exam / imaging evidence
(differs from conversion, which has specific NEURO and POST-STRESSOR)
hypochondriasis
somatoform disorder
preoccupation/fear of having serious illness despite medical evaluation & assurance.
often, mistinterpretation of normal bodily symptoms (gas = colon cancer). associated w/ Dr. shopping
body dysmorphic disorder
think body is pathologically flawed, when in fact, it is not.
chromosome 3p deletion
VHL
von-Hippel Lindau
autosomal DOMINANT.
cerebellar hemangioblastomas, clear cell renal carcinoma, and pheochromocytoma.
RCC develops in 40% of patients.
tumor supressor
cerebellar hemangioblastoma, clear cell renal carcinoma, pheochromocytoma
VHL (tumor supressor chr. 3)
location of RB
chr. 13
osteosarcoma and retinoblastoma
location of NF-1
chr. 17
WT-1 location
chr. 11
location of chemoreceptor trigger zone (area postrema)
dorsal surface of medulla, caudal end of fourth ventricle.
adhesion molecules
integrin, cadherin, selectin, Ig superfamily members