TEST 2 PHARM

Question 1

SUFFIX FOR BENZO

Answer 1

EPAM

DIAZEPAM, LORAZEPAM, CHLORDIAZEPOXIDE, CLORAZEPATE, OXAZEPAM, CLONAZEPAM

Question 2

MECH OF ACTION: BENZO

Answer 2

ENHANCE INHIBITORY EFFECTS OF GAMMA-AMINOBUTYRIC ACID (GABA) IN CNS.

RELIEF FROM ANXIETY OCCURS RAPIDLY AFTER ADMIN

Question 3

OTHER USES FRO BENZOS BESIDES ANXIETY

Answer 3

SEIZURE, INSOMNIA, MUSCLE SPASM, ALC WITHDRAWL, INDUC OF ANESTHESIA, AMNESIC PRIOR TO SURGERY

Question 4

SIDE EFFECTS: BENZOS

Answer 4

SEDATION. LIGHT HEADEDNESS, ATAXIA (LOSS OF COORDINATION), DECREASED COGNITIVE FUNCTION

IV ADMIN CAN CAUSE HYPOTENSION, CARDIAC ARREST, RESP DEPRESSION

AVOIDING DRIVING AND ALCOHOL/OTHER CNS DEPRESSANTS

ORAL OVERDOSE GASTRIC LAVAGE, ACTIVATED CHARCOAL, SALINE CATHARTICS (CAUSES FLUID TO RETURN TO GI AND STIMULATES PERISTALSIS). ADMIN FLUIDS TO INCREASE BP

Question 5

HOW TO ADMIN BENZO

Answer 5

IF TAKEN OFF TAPER TO LOWER DOSE OVER SEVERAL WEEKS

TAKE WITH FOOD

DO NOT CRUSH/CHEW TABS, SUSTAINED RELEASE

Question 6

ATYPICAL ANXIOLYTIC/NONBARBITURATE ANXIOLYTICS MOST COMMON DRUG

Answer 6

BUSPIRONE

Question 7

BENEFIT OF BUSPIRONE OVER OTHER ANTI-ANXIETY MEDS

Answer 7

LESS POTENTIAL FOR DEPENDENCY

BINDS TO DOPAMINE/SEROTONIN RECEPTORS. NO SEDATION/CNS DEPRESSION

EFFECTS DEVELOP SLOWLY. INITIAL RESPONSE TAKES 1 WEEK. FULL EFFECT TAKES UP T 4 WEEKS. IS NOT SUTIABLE FOR PRN.

Question 8

RISKS OF BUSPIRONE

Answer 8

DONT TAKE WHILE PREGNANT/BREASTFEEDING. NOT RECOMENDEED FOR KIDNEY/LIVER PTS. DONT USE WITH MAOI ANTIDEPRESSANTS OR ELSE HYPERTENSIVE CRISIS CAN OCCUR

AVOID ERYTHOMYCIN, KETOCONAZOLE, ST JOHNS WORT, GRAPEFRUIT

Question 9

HOW TO ADMIN BUSPIRONE

Answer 9

TAKE W/ FOOD. TOLERANCE, DEPENDENCE NOT A CONCERN. MUST BE TAKEN REGULARLY TO WORK

Question 10

SUFFIX FOR TRICYCLIC ANTIDEPRESSANTS

Answer 10

INE

IMIPRAMINE, DOXEPIN, NORTRIPTYLINE, AMOXAPINE, TRIMIPRAMINE, DESIPRAMINE, CLOMIPRAMINE

Question 11

MECH OF ACTION: TRICYCLIC ANTIDEPRESSANTS

Answer 11

BLOCK REUPTAKE OF NOREPINEPHRNE/SEROTONIN IN THE SYNAPTIC SPACE, INTNSIFYING EFFECTS OF NEUROTRANSMITTERS.

CAN TAKE 10-14 DAYS OR LONGER TO WORK. MAX EFFECTS NOT SEEN UNTIL 4-8 WEEKS.

Question 12

OTHER USES: TRICYCLIC ANTIDEPRESSANTS

Answer 12

NEUROPATHIC PAIN, FIBROMYALGIA, ANXIETY, INSOMNIA, BIPOLAR, OCD, ADHD

Question 13

SIDE EFFECTS: TRICYCLIC ANTIDEPRESSANTS

Answer 13

ORTHOSTATIC HYPOTENSION, DECREASED SEIZURE THRESHOLD, ECESSIVE SWEATING, INCREASED APPETITE, ANTICHOLERGENIC EFFECTS (DRY MOUTH, BLURRED VISION, PHOTOPHOBIA, URINARY RETENTION, CONSTIPATION, TACHYCARIDA)

CAUSE CAUSE SEDATION BUT EFFECTS USUALLY DIMINISH OVER TIME

EASY TO OVERDOSE ON SO CANNOT PRESCRIBE MORE THAN ONE WEEKS WORTH

PREGNANCY RISK

INCREASE SUICIDE RISK

Question 14

SUFFIX: SSRI (HINT: MIX)

Answer 14

CITALOPRAM, ESCITALOPRAM, PAROXETINE, SERTRALINE

Question 15

DIFFERENCE BETWEEN MECH OF ACTION OF TRICYCLYIC ANTIDEPRESSANTS AND SEELCTIVE SEROTONIN REUPTAKE INHIBITORS

Answer 15

TRI ANTID: BLOCKS SEROTONIN AND NOREPINEPHRINE.

SSRI: JUST BLOCKS SEROTONIN, ALSO USED FOR PANIC DISORDERS AND BULEMIA

Question 16

SIDE EFFECTS: SSRI

Answer 16

CNS STIMULATION (INSOMNIA, AGITATION, ANXIETY)

WEIGHT CHANGES (WEIGHT LOSS AT FIRST, FOLLOWED BY WEIGHT GAIN)

SEXUAL DYSFUNCTION

SEROTONIN SYNDROME (HYPERREFLEXIA, CONFUSION, HALLUCINATIONS, ANXIETY) GIVE MEDS TO CREATE SEROTONIN BLOCKADE, COOLING BLANKETS, ANTICONVULSANTS, ARTIFICIAL VENTILATION IF NECESSARY

WITHDRAWAL SYNDROME IF STOPPED SUDDENLY

HYPONATERMIA IN OLD PEOPLE.

RASH, SLEEPINESS, GI BLEED, BRUXISM (TEETH GRIND)

Question 17

HOW DO SSRI INTERACT WITH OTHER SUBSTANCES

Answer 17

SYNERGYSTIC W/ WARFARIN, LITHIUM, TRICYCLIC ANTIDEP, NSAIDS, ANTICOAGS, TCA, MAOI, ST JOHNS WORT

Question 18

NAME THE 2 SNRI TO KNOW

Answer 18

MIRTAZIPINE (BETTER THAN SSRI B/C EFFECTS OCCUR SOONER W/ LESS SEXUAL DYSFUNCTION)

TRAZODONE (GOOD FOR INSOMNIA PTS)

Question 19

WHY USE MONOAMINE OXIDASE INHIBITORS

Answer 19

FIRST-LINE TREATMENT FOR ATYPICAL DEPRESSION.

Question 19

DIFFERENCE BETWEEN SSRI AND SNRI

Answer 19

SNRI ALSO INHIBITS NORENEPIPHRINE

Question 20

3 MONOAMINE OXIDASE INHIBITORS

Answer 20

ISOCARBOXAZID, TRANYLCYPROMINE, SELEGILINE (PATCH)