Test 2 - German - Lipids and FA's

Question 1

Chylomicron t-port. Name the 7 steps.

Answer 1

Bile salts form mixed micelles from fats.
Intestinal ligases breakdown triacylglycerols.
FA are converted into triacylglycerolds
TAGs are added with cholesterol and apolipoproteins into chylomicrons.
Chylomicrons move thru the lymph to tissues.
Lipoprotein lipase converts TAGs to FAs and glycerol.
FAs oxidized as fuel or reesterified for storage.

Question 2

FAs are transported in 2 ways. Name them

Answer 2

Serum albumin - free FAs

Lipoproteins

Question 3

Look at slide 7 of lipid lecture for cholesterol t-port.

Answer 3

Do it.

Question 4

What transports fatty acrylic-CoA into the mitochondria for oxidation?

Answer 4

Acyl-Carnitine Shuttle

Question 5

What is the RLS of fatty acid beta oxidation?

Answer 5

Acrylic-CoA dehydrogenase. FADH2 is formed from this.

*Per oxidation step, 1 Acetyl-CoA, 1 NADH and 1 FADH2 are formed

Question 6

When are ketone bodies produced?

Answer 6

When oxalaoacetate is limited.

Question 7

What are the products of ketone formation?

Answer 7

Acetoacetate, d-beta-hydroxybutyrate, acetone

Question 8

What is the primary enzyme of ketone body formation?

Answer 8

HMG-CoA synthase

Question 9

What is NADPH?

Answer 9

Anabolic electron donor produced from the PPS and the citrate shuttle

Question 10

What does PKA do to ACC?

Answer 10

Inactivates it by phosphorylating it.