T4-Hypertensive Disorders Flashcards
Both gestational HTN and preeclampsia occurs 20 weeks after gestation. How do we determine the difference?
Preeclampsia is 20 weeks after gestation AND has proteinuria!
If a patient is preeclamptic, they are 20 weeks gestation or more and have proteinuria. How do we know they have proteinuria. (2 ways)
- Proteinuria at or above 30 mg (1+ or greater on dipstick) in 2 random samples at least 6 hr apart
OR
- Protein is 300 mg or more in 24 hours
* both in absence of UTI!
_____ is HTN w/o proteinuria after 20 weeks gestation
Gestational HTN
If patient has G. HTN, when does BP return to normal?
1-12 weeks after delivery
What is preeclampsia?
HTN and proteinuria developed after 20 weeks!!!!
What is mild preeclampsia?
- BP 140/90 2x 4-6 hours apart
- MAP greater than 105
- 24 hour urine protein is 300 mg or greater (0.3 g)
What is severe preeclampsia?
- BP 160/110 or greater
- MAP greater than 105
- Urine protein greater than 2 grams in 24 hours
What can preeclampsia progress to?
HEELP syndrome or eclampsia
What is often the first sign of preeclampsia?
Elevated BP
What are some other signs of preeclampsia other than the elevated BP?
- Weight gain of more than 4.4 lbs in 1 wk
- Edema in face, hands or abdomen that does not respond to 12 hours of bed rest
- DTRs/clonus
- Hyperreflexia
- Blurred vision
- Headaches
- Liver functions
- Epigastric pain (RUQ)
- Low platelets (precursor to HEELP)
- Proteinuria
What is the only cure to preeclampsia?
Deliver baby
What is the etiology of preeclampsia?
Disruption in placental perfusions and endothelial cell dysfunction
Cause of preeclampsia:
Placental ischemia is thought to cause the endothelial cell dysfunction by stimulating the release of a substance toxic to endothelia cells. What does this anomaly cause?
Generalized vasospasm
- poor tissue perfusion
- increased peripheral resistance and BP
- increased endo cell permeability–> less plasma volume
Preeclampsia:
The main pathologic factor is NOT an increase in BP but _____ as a result of ____ and ____
Poor perfusion as a result of vasospasm and reduced plasma volume
_____ causes many of the common signs and symptoms of preeclampsia
Endothelial cell dysfunction