T2DM - Drug treatment

Question 1

If HbAlc levels are not controlled, and rise to ?% (?mmol/mol) or higher, start
drug treatment.
—-o Individual HbAlc targets can be reduced on a case-by-case basis if
there are no real benefits to tight control, e.g. low ? ? or high risks of ? events.

Answer 1

7.5
58
life exp
hypose

Question 2

Offer a ?, such as standard-release ? as first line drug treatment unless contraindicated, titrated ?;

o ?mg with breakfast for ? week(s)
o ?mg with breakfast and dinner for ?week(s)
o ?mg with breakfast, lunch and dinner thereafter.

Answer 2

biguanide
met
upwards
500
one
500
one
500

Question 3

If ? is not tolerated or contraindicated, consider;
o A gliptin (?-? inhibitor).
• Sitagliptin, Lanagliptin etc.
o A ? (PPAR-Y activator).
• Pioglitazone.
o A ?.
• Glibenclamide, Gliclazide.

Answer 3

metformin
DPP-4
thiazolidinedione
sulphonylurea

Question 4

If first line therapy is not effective (>? mmol/L);
o ? + a second drug listed above.
o If ? contraindicated
• Any ? of the drugs listed above.

Answer 4

58
metformin
metformin
two

Question 5

If combination therapy is not effective·
o ? therapy; '
• ? .
• A ?.
• A ?/?.
o If metformin contraindicated 
•  Consider ? regimens

Answer 5

triple
metformin
sulphonylurea
gliptin/pioglitazone
insulin

Question 6

Self monitoring blood glucose kits are ? routinely required in ? with T2DM, but may be advised if the patient is at risk of ? events

Answer 6

not
adults
hypo