T Helper Cell Differentiation

Question 1

Th0 cells secrete?

Answer 1

IL-2, IL-4, IFN-gamma

Question 2

Th1 cells differentiate from?

Answer 2

IL-12 and IFN-gamma

Question 3

Th1 cells produce?

Answer 3

IL-2 and IFN-gamma

Question 4

Th2 cells differentiate from?

Answer 4

IL-4 and IL-10

Question 5

Th2 cells produce?

Answer 5

IL-4, IL-5, IL-10, IL-13

Question 6

Th17 cells differentiate from?

Answer 6

IL-1B, IL-6, IL-21

Question 7

Th17 cells produce?

Answer 7

IL-17, IL-21, IL-22

Question 8

Tregs produce?

Answer 8

TGF-B, IL-4, IL-10

Question 9

Produces IL-2, IL-4, IFN-gamma

Answer 9

Th0

Question 10

Produces IL-2, IFN-gamma?

Answer 10

Th1 cells

Question 11

Produces IL-4, IL-5, IL-10, IL-13?

Answer 11

Th2 cells

Question 12

Produces IL-17, IL-21, IL-22?

Answer 12

Th17 cells

Question 13

Produces TGF-B, IL-4, IL-10?

Answer 13

T-reg cells

Question 14

Produced by IL-12 and IFN-gamma?

Answer 14

Th1 cells

Question 15

Produced by IL-4 and IL-10?

Answer 15

Th2 cells

Question 16

Produced by IL-1B, IL-6, and IL-21?

Answer 16

Th17 cells

Question 17

Tregs have what markers on their cell surface?

Answer 17

CD4
CD25
Fox P3

Question 18

Th1 cells function to?

Answer 18

“Type 1 immune response” (cell mediated immunity)

• Activate NK Cells
• Activate CTL cells
• Activate macrophages to increase phagocytosis
• Upregulate Th1 and activate other T-cells to become Th1
• B cells to undergo isotype switch to IgG3
• Downregulates Th2 response
• Activated against intracellular pathogens

Question 19

Th2 cells function to?

Answer 19

“Type 2 immune responses” (humoral immunity)

• influence B cell isotype switch to IgG1, IgG2, IgG4, IgA or IgE
• promote activation of other T-cells to Th2
• Downregulate Th1
• Recruits eosinophils and basophils
• influence plasma cells v.s. Memory B differentiation
• Activated against extracellular antigens

Question 20

Th17 cells function to?

Answer 20

• Involved in autoimmune diseases (RA, MS, psorasis, gut inflammation)
• Anti-fungal
• Increases production of neutrophils

Question 21

T-reg cells function to?

Answer 21

• Regulates the immune response
• Downregulates host response to foreign antigens
• Prevents Th0 cells from responding to self antigens