T Helper Cell Differentiation Flashcards
Th0 cells secrete?
IL-2, IL-4, IFN-gamma
Th1 cells differentiate from?
IL-12 and IFN-gamma
Th1 cells produce?
IL-2 and IFN-gamma
Th2 cells differentiate from?
IL-4 and IL-10
Th2 cells produce?
IL-4, IL-5, IL-10, IL-13
Th17 cells differentiate from?
IL-1B, IL-6, IL-21
Th17 cells produce?
IL-17, IL-21, IL-22
Tregs produce?
TGF-B, IL-4, IL-10
Produces IL-2, IL-4, IFN-gamma
Th0
Produces IL-2, IFN-gamma?
Th1 cells
Produces IL-4, IL-5, IL-10, IL-13?
Th2 cells
Produces IL-17, IL-21, IL-22?
Th17 cells
Produces TGF-B, IL-4, IL-10?
T-reg cells
Produced by IL-12 and IFN-gamma?
Th1 cells
Produced by IL-4 and IL-10?
Th2 cells
Produced by IL-1B, IL-6, and IL-21?
Th17 cells
Tregs have what markers on their cell surface?
CD4
CD25
Fox P3
Th1 cells function to?
“Type 1 immune response” (cell mediated immunity)
- Activate NK Cells
- Activate CTL cells
- Activate macrophages to increase phagocytosis
- Upregulate Th1 and activate other T-cells to become Th1
- B cells to undergo isotype switch to IgG3
- Downregulates Th2 response
- Activated against intracellular pathogens
Th2 cells function to?
“Type 2 immune responses” (humoral immunity)
- influence B cell isotype switch to IgG1, IgG2, IgG4, IgA or IgE
- promote activation of other T-cells to Th2
- Downregulate Th1
- Recruits eosinophils and basophils
- influence plasma cells v.s. Memory B differentiation
- Activated against extracellular antigens
Th17 cells function to?
- Involved in autoimmune diseases (RA, MS, psorasis, gut inflammation)
- Anti-fungal
- Increases production of neutrophils
T-reg cells function to?
- Regulates the immune response
- Downregulates host response to foreign antigens
- Prevents Th0 cells from responding to self antigens
