Cytokines Flashcards
IL-1 alpha/beta
Macrophages, epithelial cells
*Induces fever, pro-inflammatory
IL-2
T cells (naive, Th0, Th1) *Growth factor
IL-4
Th2 cells, mast cells
*Promote Th2 differentiation, B cell activation, B cell switch to IgE
IL-5
Th2, Mast cells
*promotes eosinophilia
IL-6
Th2 cells, macrophages, endothelial cells
*promote T and B cell growth, acute phase protein production, induces fever
IL-7
Stromal cells
*Promotes development of B and T cell progenitors
IL-8
Macrophages, endothelial/epithelial cells
*chemotactic factor for neutrophils and other granulocytes
IL-10
Monocytes, T cells, certain B cell subsets
*suppress macrophages and CTL, B cell growth factor
IL-12
Macrophages, dendritic cells
*Promotes Th1 differentiation, activates NK cells
IL-13
Th2 cells
*Promotes T/B cell growth, acute phase protein production, induces fever, inhibits macrophages
IL-17
Th17 T cells
*Increases neutrophil production, pro-inflammatory
IL-21
Th2 cells
*Proliferation of B, T, and NK cells
IL-22
NK cells, Th17 cells
*induces acute phase proteins, pro-inflammatory
IL-23
Dendritic cells, monocytes/macrophages
*Promotes development/proliferation of Th17 cells
TNF-alpha
Macrophage, NK cells, T cells
*promotes inflammation
Lymphotoxin-alpha
T and B cells
*induces apoptosis of targets
BAFF (Blys)
B cells
*Induces B cell proliferation, maturation, and survival
TGF-Beta1
Monocytes, T-cells, certain B cell subsets
*inhibits cell growth, anti-inflammatory, promotes IgA switch
IFN-alpha
all nucleated cells
*anti-viral, increases HLA Class I expression
IFN-beta
Fibroblasts
*anti-viral, increases HLA Class I expression
IFN-gamma
T cells, NK cells
*increases macrophage activation, HLA I and II expression
