Antibacterial MOAs

Question 1

Inhibit synthesis of bacterial cell walls

Answer 1

Penicillins, Cephalosporins, Vancomycin, Bacitracin

Cycloserine, azole antifungals (clotrimazole, fluconazole, itraconazole)

Question 2

Alters cell membrane permiability

Answer 2

Detergents - Polymyxin B*

Polyene antifungal agents (amphotericin B, nystatin)

Question 3

Inhibition of bacterial protein synthesis by 50S subunit

Answer 3

Chloramphenicol, macrolides (Erythromycin, azithromycin, clarithromycin, telithromycin), clindamycin, quinupristin/dalfopristin, linezolid

Question 4

Inhibition of protein synthesis by 30S subunit

Answer 4

Aminoglycosides (streptomycin, tobramycin, gentamycin, amikacin), Tetracyclines (tetracycline, minocycline, doxycycline)

Question 5

Inhibit DNA gyrase (topoisomerase)

Answer 5

Fluoroquinolones (ciprofloxacin, Levofloxacin)

Question 6

Inhibit mRNA synthesis via DNA dependent RNA polymerase

Answer 6

Rifampin

Question 7

Metabolic analogs - block folate synthesis

Answer 7

Trimethoprim, Sulfonamides

Question 8

Metabolic analogs - Inhibit synthesis of mycolic acids

Answer 8

Isoniazid