T cell Clinical Case Flashcards
1
Q
T cell immune deficiency general presentation
A
- increased susceptibility to some viral, fungal and parasitic/protozoan infection
2
Q
examples of T cell immune deficiencies
A
- DiGeorge
- Chronic Mucocutaneous Candidiasis
3
Q
DiGeorge syndrome due to
A
- thymic aplasia
- no thymus or a very small amount of tissue
4
Q
DiGeorge syndrome symptoms
A
- heart defects
- low calcium
- T cell deficiency
- cleft palate
5
Q
Chronic Mucocutaneous Candidiases symptoms
A
- non-invasive skin infections with yeast
6
Q
combined immune deficiencies examples
A
- SCID
- Wiskott-Aldrich syndrome
7
Q
Wiskott-Aldrich syndrome symptoms
A
- abnormal platelets
- eczema
- recurrent infections
8
Q
classic triad of DiGeorge syndrome
A
- conotruncal cardiac abnormalities - heart defect
- hypoplastic thymus - there in small numbers
- hypocalcemia (due to parathyroid hypoplasia)
9
Q
DiGeorge syndrome usually due to a defect in which chromosome?
A
- 22q11.2
10
Q
degree of T cell defect DiGeorge
A
- most mild
- 0.5%-1% complete absense
11
Q
which laboratory tests do you order first?
A
- CBC with differential
- first want to know if cells are present
- diff gives you what % of lymphocytes
12
Q
mitogens
A
- stimulate cells to divide by mitosis
13
Q
partial DGS vs Complete DGS
A
- describes level of immune function
- and degree of thymic hypoplasia
14
Q
partial DGS
A
- variable and non-life threatening immune defect
- recurrent sinopulmonary infections
- degree of immune dysfunction may improve with age
15
Q
complete DGS
A
- form of SCID
- usually fatal in first year of life
16
Q
transplants for complete DGS
A
- thymus transplant
- stem cell transplant - more frequently
