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IMM Exam 1 > Cytokines > Flashcards

Cytokines Flashcards

1
Q

characteristics of cytokines

A
  • pleiotropic
  • redundant
  • multifunctional
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2
Q

pleiotropic

A
  • a particular cytokines can act on a number of different types of cells rather than a single cell type
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3
Q

redundant

A
  • the ability of cytokines to carry out the same function
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4
Q

multifunctional

A
  • the same cytokines is able to regulate a number of different functions
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5
Q

four functional categories of cytokines

A
  • innate immune
  • adaptive immume
  • chemokines that produce directed-cell migration
  • hematopoiesis
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6
Q

hematopoiesis cytokines

A
  • IL-3
  • IL-7
  • G-CSF
  • M-CSF
  • GM-CSF

TOP 10 = 3+7

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7
Q

innate immunity cytokines

A
  • IFN-y
  • IFN-B
  • IFN-a
  • TNF
  • TBF-B
  • chemokines
  • IL-1
  • IL-6
  • IL-10
  • IL-12

SIX LETTERS IN INNATE
ONE SEX FROM 10-12

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8
Q

adaptive immunity cytokines

A
  • IFN-y
  • TGF-B
  • IL-2
  • IL-4
  • IL-5
  • IL-13
  • IL-17
  • IL-22

8 THINGS INCLUDED

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9
Q

IL-1 secreted by

A
  • macrophages
  • endothelial cells
  • some epithelial cells
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10
Q

IL-1 effect

A
  • endothelial cell activation (pro-inflammation)
  • neutrophil activation
  • FEVER
  • acute phase protein synthesis
  • TH17 differentiation

HOT

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11
Q

IL-2 secreted by

A
  • CD4 and CD8 T cels
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12
Q

IL-2 effect

A
  • survival, proliferation, and differentiation of effector and regulatory T cells

T

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13
Q

IL-4 secreted by

A
  • CD4 T cells

- mast cells

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14
Q

IL-4 effect

A
  • B cell switching to IgE

stE

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15
Q

IL-5 secreted by

A
  • CD4 T cells

- mast cells

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16
Q

IL-5 effect

A
  • Activation of eosinophils

steA

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17
Q

IL-6 secreted by

A
  • macrophages
  • endothelial cells
  • T cells
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18
Q

IL-6 effect

A
  • stimulates production of aKute phase proteins
  • PROLIFERATION OF ANTIBODY PRODUCING CELLS
  • steaK

Hot T-bone stEAK

19
Q

IL-12 secreted by

A
  • macrophages

- dendritic cells

20
Q

IL-12 function

A
  • activation of NK cells and T cells
  • production of IFN-gamma
  • TH1 differentiation
21
Q

interferon gamma secreted by

A
  • CD4 and CD8 cells (innate and adaptive)

- natural killer cells (innate and adaptive)

22
Q

interferon gamma function

A
  • activation of macrophages (innate and adaptive)
23
Q

TNF secreted by

A
  • macrophages

- T cells

24
Q

TNF function

A
  • endothelial cell activation (inflammation)
  • action of neutrophils
  • fever
  • acute phase protein synthesis
  • apoptosis of many cell types

BASICALLY THE SAME AS IL-1

25
Q

IL-10 secreted by

A
  • macrophages
  • dendritic cells
  • T cells
26
Q

IL-10 function

A
  • atTENuates inflammation (ANTI-INFLAMMATORY CYTOKINE)
  • activates macrophages and dendritic cells
  • inhibits IL-12 production
  • decreases expression of MHC Class I and TH1 cytokines
27
Q

TGF-beta secreted by

A
  • CD4 cells

- many cell types

28
Q

TGF-beta function

A
  • Both TGF-B and IL-10 atTenuate inflammation
  • inhibition of T cel activation
  • differentiation of regulatory T cells
29
Q

Interferon alpha and beta secreted by

A
  • virus infected cells
30
Q

interferon alpha and beta function

A
  • prime uninfected cells for viral defense
31
Q

chemokines secreted by

A
  • macrophages
  • dendritic cells
  • endothelial cells
32
Q

chemokines function

A
  • leukocyte chemotaxis

- integrin activation

33
Q

IL-17 secreted by

A
  • CD4 T cells

- other cells

34
Q

IL-17 function

A
  • stimulation of acute inflammation
35
Q

IL-17 hematopoiesis

A
  • survival and proliferation of immature B lymphocytes and T-lymphocyte precursors
  • produced mainly by fibroblasts and bone marrow stromal cells
36
Q

inflammatory cytokines

A
  • IL-1
  • IL-6
  • IL-8
  • TNF-alpha
37
Q

interferon alpha and beta secreted by

A
  • alpha: dendritic cells and macrophages

- beta: fibroblasts

38
Q

interferon alpha and beta function

A
  • antiviral state

- increase MHC class I expansion

39
Q

examples of cytokines

A
  • CXCL8
  • CXCL2
  • CCL2
  • CCL21
40
Q

CXCL8

A
  • recruitment of neutrophils
41
Q

CXCL2

A
  • recruits naive T cells
42
Q

CCL2

A
  • helps activate and recruit macrophages
43
Q

CCL21

A
  • recruits naive T cells to secondary lymphoid tissues

IMM Exam 1 (20 decks)

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