syphillis Flashcards
cause of syphillis
treponema pallidum
routes of infection
sexually intimate contact - oral, ana, vaginal blood -trans placental -blood transfusion
characteristic sign of primary syphilis
chancre at site of infection
painless except in the anal region
evolution
primary
secondary
latent
tertiary
what is treponema pallidum
a mobile spirochete that’s thin enough to pass between cells
what characterises secondary syphyillis
flu like symptoms
condyloma lata
what disease is usually concomiitant with syphyills
HIV both increases the risk of acquiring syphyllis and has it’s risk of acquisition raised by syphillis
incubation period from infection first signs
10-90 days
21 days average
chancre characteristics
coin like size
painless ulcer
can be unnoticed if inside the anus or vagina
primary syphilliss symptoms
chancre
regional lymphadenopathy after 5 weeks (INGUIINAL/ CERVICAL)
primary syphyliss DX
ulcer: ulcers of another cause
lab tests fofr primary syphillis
dark field microscopy
RPR- can be false +/-
VDRL- can be false +/-
skn biopsy
chancre biopsy shows what
t pallidum spirochete
monoleukucyte infiltrates
macrophages
lymphocytes
cause of secondary syphyliss
hematogenous spread of t pallidum
what does tertiary syphyllis consist of
cardiovascular syphyllis
neurosyphylis
