bullous pemphigoid

Question 1

what is it

Answer 1

autoimmune disease involving ab attack on collagen 17 in the hemi desmosomes anchoring the keratinocytes to the the BM

Question 2

epi

Answer 2

elderly

neurological diseases d.2 accum of collagen 17

Question 3

clinical ft’s

Answer 3

large tense bullae
lower extremities and skin folds
less likley to rupture but when they do they cause erosions

Question 4

dg

Answer 4

clinical pres
skin biopsy of early blisterss
-shows neutropjilic infiltrate below dermis and eosinophils

direct immunoflorrescence
-ab’s along bm
blood test for circ ab’s against type 27 collagen

Question 5

rx

Answer 5

strong topical steroids

-CLOBESTASOL PROPIONATE