Pemphigus Vulgaris

Question 1

dg

Answer 1

skin biopsy,

• rounded-up separated keratinocytes (called acantholytic cells) within the blisters just above the basal layer of the epidermis
• tombstone appearance of granular layer d/2 sep

immunofluorescence staining of the skin biopsy sections to reveal antibodies

-+ve nikolsky

Question 2

scoring of severityy

Answer 2

Pemphigus Disease Area Index

Question 3

sx

Answer 3

initial oral mucosal blistering followed by skin
painful
slow healing
hoarse vouce w/ laryngeal involvement

Question 4

describe blister

Answer 4

thin walled w/ clear fluid

superficial

vegetative erosions in kin folds called PEMPHIGUS VEGETANS

Question 5

epidemiology

Answer 5

most commonly between the ages of 50-60 years, and is more common in Jews andIndians presumably for genetic reasons

Question 6

rx

Answer 6

bno cure 
-reduce blisters
-prevent 2ndary inf
-
Oral corticosteroids are the mainstay of medical treatment for controlling the disease

other immuno suppressives

• rituximab
• cyclophosphamide
• dapsone

minimixe skin trauma

• spicy had or acisic food
• contact sport

Question 7

def

Answer 7

autoimmune disease characterized by superficial blisters in skin and mucous membranes

Question 8

etio

Answer 8

(IgG) autoantibodies bind to a protein called desmoglein 3, which is found in desmosomes in the keratinocytes near the bottom of the epidermis. The result is the keratinocytes separate from each other, and are replaced by fluid, the blister.