Syndromes and other shit Flashcards
What does SLE stand for?
Systemic lupus erythematosus
What is SLEß
Multi-systemic autoimmune disease
What occurs in SLE?
Autoantibodies are made against variety of auto antigens (anti-nuclear antibody)
How do SLE autoantibodies cause damage?
Immune complex deposition and complement activation
What are the clinical features of SLE?
ANA and DNA in 60% +ve
Malar rash in 50%
ESR raised but CRP normal
What is ESR (blood test)?
Erythrocyte sedimentation rate
What is Churg-Strauss Syndrome?
Triad of adult onset asthma, eosinophilia and vasculitis (vasospasm/MI/DVT)
Churg strauss affects which tissues?
Lungs
Heart
Skin
What kind of syndrome may occur in Churg-Straussß
Systemic inflammatory response syndrome - glomerulonephritis especially if ANCA +ve
What is ANCA?
Auto-neutrophil cytoplasmic autobody
What are investigation features of Churg-Strauss?
pANCA positive
Eosinophilic infiltrate
Granulomas
What is Caplan’s Syndrome?
Multiple lung nodules in coal workers with rheumatoid arthritis
What causes Caplan’s syndrome?
Inflammatory reaction to anthracite (silica, asbestos)
What is seen on CXR with Caplan’s Syndrome?
Bilateral peripheral nodule
What is Goodpasteur’s Syndrome?
Acute glomerulonephritis and lung symptoms
Which lung symptom is associated with Good pasture’s syndrome?
Haemoptysis
What is found histopathologically in Good-pasture’s syndrome?
Antiglomerular basement membrane antibodies
What is found on CXR with Good Pasture’s syndrome?
Infiltrates due to pulmonary haemorrhage (lower zones)
What is Wegener’s Granlomatosis?
Necrotising granulomatous inflammation and vasculitis of small and medium vessels
What is seen on CXR with Wegener’s Granulomatosis?
Fluffly infiltrates of pulmonary haemorrhage
What would be found in blood tests for Wegener’s Granulomatosis?
cANCA raised
Raised CRP/ESR
Which characteristic rash is found in SLE?
Butterfly rash
SLE predominantly affects?
Women
Management of Wegener’s Granulomatosis requires?
Long term immunosuppression
Wegener’s Granulomatosis has two components. Name these.
Granulomatosis
Polyangitis
What is polyangitis?
Inflammation of multiple blood or lymph vessels
What is the other term for Wegener’s Granulomatosis?
Granulomatosis with Polyangitis (GPA)
What does ACOS stand for?
Asthma COPD Overlying Syndrome
What is ACOS?
COPD with eosinophilia
