Sarcoidosis Flashcards
What is sarcoidosis?
Multi-system Idiopathic non-caseating granulomatous disease
What type of hypersensitivity causes sarcoidosis?
Type IV hypersensitivity
What is the epidemiology of sarcoidosis?
More common in northern Europe, adults, females and Afro-Carribeans
Which tissues are usually involved in Sarcoidosis?
Lungs lymph nodes joints Liver Skin Eyes Kidneys Brain Nerves Heart
What are acute clinical features of Sarcoidosis?
Erythema nodosum BHL Arthritis Uveitis Parotitis Fever
What are chronic clinical features of Sarcoidosis?
Lung infiltrates (alveolitis) Skin infiltrations Peripheral lymphadenopathy Hypercalcaemia Other organs affected Hepatomegaly Splenomegaly
Which investigations would be performed for Sarcoidosis?
CXR Tissue biopsy Pulmonary function Blood tests CT Thorax
What would be seen on CXR?
Bilar helar lymphadenopathy
What would be seen on a CT of the thorax in Sarcoidosis?
Peripheral nodular infiltrate
What would be found on tissue biopsy?
Non-Caseating granuloma
What type of pattern would a pulmonary function test for Sarcoidosis show?
Restrictive pattern
What would blood tests show for Sarcoidosis?
increased ACE
Increased Calcium
Increased Immunoglobulin
How is acute Sarcoidosis treated?
Self-limiting (bed rest, NSAIDs)
How is chronic Sarcoidosis treated?
Oral steroids if vital organ affected
What are indications for corticosteroid treatment?
Parenchymal lung disease
Uveitis
Hypercalccaemia
Neuro or cardio involvement
