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Pharmacology Final > Sulfonamides > Flashcards

Sulfonamides Flashcards

1
Q

Sulfonamides
PO
absorbed

A

sulfioxazole
sulfamethoxazole
sulfadiazine

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2
Q

sulfonamides

po NOT absorbed

A

sulfazalacine

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3
Q

Topical Sulfonamides

A

sulfacetamide
Silver sulfadiazine
manefide

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4
Q

mechanism of Sulfonamides

A

inhibit folate synthesis
PABA-> DHF
(PABA analogs)

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5
Q

sulfisoxazole

use

A

oral absorbed

- super water soluble- otitis media in kids

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6
Q

sulfamethoxazole

use

A

oral absorbed
+ with trimethorpin

SMX TMP

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7
Q

sulfadiazine

use

A

oral absorbed
Tx. T. Gondii + pyrimethamine
crosses BBB

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8
Q

sulfasalazine

use

A

oral NOT absorbed

anti-inflammatory agent to tx Chrons and RA

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9
Q

sulfasalazine

converted to?

A

5 amino salycylate

which is why its not absorbed and used to tx inflammatory rxna

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10
Q

Sulfacetamide

use

A

Acne

Trachoma infection

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11
Q

silver sulfadiazine + manefide

use

A

antibacterial for burn victims to prevent skin infections

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12
Q

Sulfonamides

resistance

A

increase synthesis of PABA

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13
Q

Sulfonamides

side effects

A 
crystalluria 
allergic reactions
nephrotoxicity 
drug interactions 
hematological rxns
C/i pregos
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14
Q

Sulfonamides

drug interaction

A

displaces drugs from albumin

warfarin, tolbutamide and methotrexate

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15
Q

hematological side effects of sulfonamides

A

hemolytic anemia
aplastic anemia
thrombocytopneia
granulocytopenia

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16
Q

why are sulfonamides C/I in Pregos at term and kids less than 2 months

A

can cause Kernicterus

displace bilirubin from albumin->- increase in CNS

17
Q

Trimethorpin

analog

A

analog of DHF

PABA- - - - > DHF- - -x- -> THF

18
Q

side effect of trimethorpin

A

megaloblastic anemia

19
Q

what do you give to counter megaloblastic anemia in patient given trimethrorpin

A

Leukovorn

20
Q

SMX TMP

what is it

A

Sulfamethoxazole Trimethorpin
synergistic combination that blocks both steps of folate synthesis

PABA- x - > DHF- x -> THF

21
Q

SMX TMP

first line

A

Haemophilus influenza
Moraxella
Enterobacter

22
Q

SMX TMP

DOC

A 
NOCARDIA
PNEUMOCYSTIS PNEUMONIA (clyndamycin back up)
23
Q

SMX TMP

side effects

A

hemolytic anemia
aplastic anemia
granulocytopenia
thrombocytopenia

megaloblastic anemia->- give leukovorn

Pharmacology Final (20 decks)

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