Sulfonamides Flashcards
Sulfonamides
PO
absorbed
sulfioxazole
sulfamethoxazole
sulfadiazine
sulfonamides
po NOT absorbed
sulfazalacine
Topical Sulfonamides
sulfacetamide
Silver sulfadiazine
manefide
mechanism of Sulfonamides
inhibit folate synthesis
PABA-> DHF
(PABA analogs)
sulfisoxazole
use
oral absorbed
- super water soluble- otitis media in kids
sulfamethoxazole
use
oral absorbed
+ with trimethorpin
SMX TMP
sulfadiazine
use
oral absorbed
Tx. T. Gondii + pyrimethamine
crosses BBB
sulfasalazine
use
oral NOT absorbed
anti-inflammatory agent to tx Chrons and RA
sulfasalazine
converted to?
5 amino salycylate
which is why its not absorbed and used to tx inflammatory rxna
Sulfacetamide
use
Acne
Trachoma infection
silver sulfadiazine + manefide
use
antibacterial for burn victims to prevent skin infections
Sulfonamides
resistance
increase synthesis of PABA
Sulfonamides
side effects
crystalluria allergic reactions nephrotoxicity drug interactions hematological rxns C/i pregos
Sulfonamides
drug interaction
displaces drugs from albumin
warfarin, tolbutamide and methotrexate
hematological side effects of sulfonamides
hemolytic anemia
aplastic anemia
thrombocytopneia
granulocytopenia
why are sulfonamides C/I in Pregos at term and kids less than 2 months
can cause Kernicterus
displace bilirubin from albumin->- increase in CNS
Trimethorpin
analog
analog of DHF
PABA- - - - > DHF- - -x- -> THF
side effect of trimethorpin
megaloblastic anemia
what do you give to counter megaloblastic anemia in patient given trimethrorpin
Leukovorn
SMX TMP
what is it
Sulfamethoxazole Trimethorpin
synergistic combination that blocks both steps of folate synthesis
PABA- x - > DHF- x -> THF
SMX TMP
first line
Haemophilus influenza
Moraxella
Enterobacter
SMX TMP
DOC
NOCARDIA PNEUMOCYSTIS PNEUMONIA (clyndamycin back up)
SMX TMP
side effects
hemolytic anemia
aplastic anemia
granulocytopenia
thrombocytopenia
megaloblastic anemia->- give leukovorn
