Fluoroquinolones

Question 1

Fluoroquinolone

mechanism of action

Answer 1

interfere bacterial DNA replication

• 2nd Gen (-) inhibits bacterial gyrase
• 3/4 Gen (-/+) inhibits gyrase and topo IV

Question 2

second generation fluoros

Answer 2

ofloxacin

ciprofloxacin

Question 3

third generation fluoros

Answer 3

levofloxacin

gemifloxacin

Question 4

fourth generation fluoros

Answer 4

moxifloxacin
gati
besi

Question 5

Spectrum for second gen fluoros

Answer 5

AEROBIC gram - Rods

Question 6

spectrum third gen fluoros

Answer 6

AEROBIC Gram - Rods

Gram + cocci

Question 7

spectrum fourth Gen fluoros

Answer 7

Aerobic Gram - rods
Gram + cocci
obligate anaerobes

Question 8

resistance of fluoros

Answer 8

altered target site due to chromosomal mutation

Question 9

which antibiotics tx intracellular organisms

Answer 9

Tetracyclines
macrolides
fluoroquinolones

Question 10

kinetics

oral

Answer 10

cipro being the least-

can decrease oral absorption- milk dietary supplements

Question 11

why are fluoroquinolone CI in pregnant

Answer 11

fluoroquinolone bind to cartilage and can cause cartilage erosion

Question 12

cipro first line for

Answer 12

[gram - aerobic]`
E coli 
Enterobacter
Pseudomonas 
Enteritis- campylobacter shigella salmonella vibrio

Question 13

Ofloxacin use

Answer 13

best one to tx urethritis due to chlamydial infections

Question 14

levofloxacin use

Answer 14

[gram - aerobic and gram +]

MDRSP

Question 15

Gemifloxacin use

Answer 15

[gram - aerobic and gram +]
sole tx for respiratory tract and bronchitis infections
MDRSP

Question 16

moxifloxacin use

Answer 16

[gram - aerobic and gram + and anaerobic bacteria]
MDRSP
hib moraxella klebsiella
mycoplasma

Question 17

gatiflocaxin and betifloxacin

Answer 17

solely for tx of bacterial conjunctivitis

Question 18

uroquid and hipped

use

Answer 18

urinary tract antiseptics

- in acidic ph they convert to formaldehyde

Question 19

nitrofurantoin

use

Answer 19

urinary tract antiseptic

- cause urine to be brown

Question 20

Linezolid use

Answer 20

complicated bacteremia endocarditis skin soft tissue infection
MRSA VRSA VRE
MDRSP

Question 21

advantage of linezolid use

Answer 21

can tx MRSA and VRSA PNEUMONIA! bc it can accumulate in lungs (sinercid and dapto cant)

Question 22

Sinercid

use

Answer 22

MRSA VRSA VISA

VRE (faecium)

Question 23

what does sinercid NOT cover

Answer 23

VRE (faecalis)

Question 24

which drugs can be given in a renal failure patient

Answer 24

moxifloxacin

sinercid!