Fluoroquinolones Flashcards
Fluoroquinolone
mechanism of action
interfere bacterial DNA replication
- 2nd Gen (-) inhibits bacterial gyrase
- 3/4 Gen (-/+) inhibits gyrase and topo IV
second generation fluoros
ofloxacin
ciprofloxacin
third generation fluoros
levofloxacin
gemifloxacin
fourth generation fluoros
moxifloxacin
gati
besi
Spectrum for second gen fluoros
AEROBIC gram - Rods
spectrum third gen fluoros
AEROBIC Gram - Rods
Gram + cocci
spectrum fourth Gen fluoros
Aerobic Gram - rods
Gram + cocci
obligate anaerobes
resistance of fluoros
altered target site due to chromosomal mutation
which antibiotics tx intracellular organisms
Tetracyclines
macrolides
fluoroquinolones
kinetics
oral
cipro being the least-
can decrease oral absorption- milk dietary supplements
why are fluoroquinolone CI in pregnant
fluoroquinolone bind to cartilage and can cause cartilage erosion
cipro first line for
[gram - aerobic]` E coli Enterobacter Pseudomonas Enteritis- campylobacter shigella salmonella vibrio
Ofloxacin use
best one to tx urethritis due to chlamydial infections
levofloxacin use
[gram - aerobic and gram +]
MDRSP
Gemifloxacin use
[gram - aerobic and gram +]
sole tx for respiratory tract and bronchitis infections
MDRSP
moxifloxacin use
[gram - aerobic and gram + and anaerobic bacteria]
MDRSP
hib moraxella klebsiella
mycoplasma
gatiflocaxin and betifloxacin
solely for tx of bacterial conjunctivitis
uroquid and hipped
use
urinary tract antiseptics
- in acidic ph they convert to formaldehyde
nitrofurantoin
use
urinary tract antiseptic
- cause urine to be brown
Linezolid use
complicated bacteremia endocarditis skin soft tissue infection
MRSA VRSA VRE
MDRSP
advantage of linezolid use
can tx MRSA and VRSA PNEUMONIA! bc it can accumulate in lungs (sinercid and dapto cant)
Sinercid
use
MRSA VRSA VISA
VRE (faecium)
what does sinercid NOT cover
VRE (faecalis)
which drugs can be given in a renal failure patient
moxifloxacin
sinercid!
