Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology Final > Macrolides > Flashcards

Macrolides Flashcards

1
Q

Macrolides

A

Erythromycin
Clarythromycin
azythromycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

mechanism of Macrolides

A

bind to 50s ribosome SU and inhibit aminoacyl translocation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Resistance of Macrolides*

A

depends of type of bacteria
Gram + : altered target site
Gram -: Enzymatic inactivation via plasmid esterase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Administration

macrolides

A

Erythromycin: NO FOOD
Clarythromycin : Y
Azythromycin : Y

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

distribution of macrolides
where do they accumulate
also concentration

A

everywhere except CSF
they accumulate in macrophages
at normal concentrations: Bacteriostatic
at higher concentrations (IV) Bactericidal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Metabolism of Erythromycin

A

p450 liver

can affect metabolism of other drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Metabolism of Clarythromycin

A

p450 kidney

can affect metabolism of other drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Metabolism of Azithromycin

A

liver

NO drug interactions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

which macrolides safe to use in Renal Failure patient

A

Erythromycin

Azithromycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

which macrolides are safe to use in hepatic failure pt

A

clarithromycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

which Macrolides have potential drug interactions

A

Erythromycin

Clarythromycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

which macrolides are contraindicated in someone with hepatic damage

A

Erythromycin

Azythromycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

all macrolides are first life for

A

C. Diphtheria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Chlarythro and azythro tx

A

MAI

chlamydia pneumonia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Erythromycin first line for

A

C. diptheria

Chanchroid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

erythromycin back up for

A

legionaire
mycoplasma
lyme disease ( Doxy-> Pnc)

17
Q

Clarythromycin first line for

A

diptheria
MAI complex
Mycobacterium Pneumoniae

18
Q

Azythromycin Drug of Choice for

A

Chlamydia Trachomatis 1 dose!

19
Q

azytrhomycin first line for

A

diptheria
MAI complex
mycobacterium pneumonia

20
Q

Telithromycin

Mechanism of Action

A

binds to 50s and inhibits amino acyl transfer but at two sites

21
Q

telithromycin

use

A

tx community acquired pneumonia*

MDRSP

22
Q

telithromycin

contraindications

A

Hepatotoxicity

  • C/i under 18 ( jaundice and liver failure)
  • in presence of hepatic disease
  • long QT interval

Pharmacology Final (20 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions