Random Protein inhibitors

Question 1

Chloramphenicol

mechanism

Answer 1

blocks binding of trna - inhibiting peptide bond formation

Question 2

chloramphenicol

back up for> and why?

Answer 2

rickettsiae (Doxycycline)
Chlamydia Pscitaci only
bacteroides
third line for bacterial meningitis

ITS SUPER TOXIC

Question 3

where is chloramphenicol used

Answer 3

in developing countries to tx salmonella cholera plague

Question 4

chloramphenicol is used as empirical tx for?

Answer 4

bacterial meningitis and encephalitis in children

Question 5

adverse effects of chloramphenicol

Answer 5

Bone marrow toxicity
- Reversible anemia (dose related)
- irreversible aplastic anemia -> pancytopenia
gray baby syndrome
super infections
drug interactions- warfarin and oral hypoglycemic agents

Question 6

grey baby syndrome

Answer 6

use of chloramphenicol in children less than 1 m
liver cannot metabolize-> glucuronidate the drug causing it to accumulate leading to damage of mitochondria cyanosis and death

Question 7

clyndamycin

mechanism

Answer 7

binds to 50S Su inhibiting translocation

Question 8

Clyndamycin Spectrum*

Answer 8

Gram + and Gram - AEROBES*

Question 9

clyndamycin use

Answer 9

tx refractory bone infection and prophylaxis in endocarditis patients

Question 10

clyndamycin side effects

Answer 10

pseudomembranous colitis due to C Diff overgrowth

C. Diff ALWAYS resistant to clyndamycin

Question 11

muriprocin mechanism of action*

Answer 11

binds to isoleucyl trna synthetase (doesnt target 30/50)

has no cross resistance!

Question 12

muriprocin

spectrum

Answer 12

gram + cocci (staph and strep)

Question 13

muriprocin

resistance

Answer 13

altered trna synthetase

Question 14

spectinomycin

use

Answer 14

MULTIDRUG RESISTANT GONOTTHEA*

Question 15

Clyndamycin

tx

Answer 15

bacteroides fragilis
fusobacterium
(clostridium)