Carbapenem and monobactams

Question 1

carpapenems

Answer 1

imipenem
meropenem
doripenem
ertapenem

Question 2

monobactam

Answer 2

azetreonam

Question 3

carbapenems used for*

Answer 3

EMPIRIC THERAPY
due to broad spectrum of activity [+/- aerobic/ anaerobic*]

also hard infections to get rid of [ extended spectrum b lactamases]

Question 4

imipenem use

Answer 4

broadest spectrum
tx enterobacter
penicillin resistant pneumonia

Question 5

meropenem has

Answer 5

more activity against gram -

Question 6

structure of carbapenem

Answer 6

5 A ring with S outside of the ring

Question 7

metabolism of imipenem?*

add?

Answer 7

metabolized in kidney by renal dehydropeptidase

you add cilastatin to prevent the buildup of toxic metabolites (primaxin)

Question 8

adverse effects

Answer 8

NVD. cross allergy w pncn

imipenem:
- can lower seizure threshold

Question 9

chemical structure of monobactam

Answer 9

single blactam without A ring

Question 10

importance of monobactams

Answer 10

(AZtreonam)

since it has no A ring it can be used in people with penicillin allergies!!!!

Question 11

aztreonam spectrum*

Answer 11

AEROBIC** GRAM - RODS

Question 12

Monobactam tx

Answer 12

serious infections [meningitis, pneumonia, sepsis]— for people allergic to pncn*
UTI
INHALATION for CF to reduce pseudomonas** infections (cayston)