Super Random Deck (2.1) Flashcards
Which drugs are used to Tx pt with Reduced Renal Function (8)
- Nafcillin
- Ceftriaxone
- doxycycline
- Tegacycline
- Erytrhomycin
- Azythromycin
- Moxifloxacin
- Synercid (Quinupristin)
Which drugs are contraindicated in pregnancy
- Tetracyclines
- Aminoglycosides
- Fluoroquinolones
- Sulfonamide
Rifampin is contraindicated with?
HIV protease inhibitors
sulfonamides and trimethorpin target what?
Folic acid production
bacteria HAVE to make it, we get it from our diet
fluoroquinolone target what?
Gyrase (Gram -)
Gyrase and Topo IV (Gram +)
which drug class is used for empiric treatment
carbapenems
- since they are such broad spectrum (+ - Aero/ anaero)
- used in a critically ill pt until you get the culture results (you give them AFTER you obtain the culture)
Which drugs are used that work after MIC
Aminoglycosides- dose dependent
Quinupristin
Under what conditions do penicillins cross BBB
and Which ones
under inflammation— can cross BBB
Pen G and Pen V to tx meningitis
Most protein Synthesis inhibitors are STATIC
EXCEPT
Aminoglycosides - BACTERICIDAL
which is why you can use a B lactam with an aminoglycoside and they won’t antagonize each other
Which drugs are Contraindicated with hepatic dysfunction
Erythromycin and Tetracyclines
Why are Tetracyclines C/I in Pregnant and kids under 8
- binds to Calcium
- causes tooth decay
- interferes with bone growth (abnormalities)
why are aminoglycosides C/I in pregnant and kids
causes ototoxicity
Why are Fluoroquinotolones C/I in pregnant and kids
- interferes with cartilage growth
Chloramphenicol
age for C/I in kids
why
DONT give to children less than 1 month
causes grey baby syndrome bc their livers cannot glucuronidate this drug leading to accumulation
Sulfonamide
age for C/I in kids
why
DONT give to children less than 2 months
sulfonamide is highly bound to albumin, can displace bilirubin from albumin leading to an increase in albumin in CNS— kernicterus
