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Pharmacology Final > Anti Parasitics > Flashcards

Anti Parasitics Flashcards

1
Q

tx tripanosoma gambiencie/ brucei

A

suramin
melasoprostol
pentamidine

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2
Q

tx trypanosoma cruzi

A

nifurtimox [knee high fur socks]

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3
Q

tx Leishmaniasis

A

stibogluconate [t bone steak]

miltefosine-

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4
Q

tx of giarda

A

metronidazole

quacrine-

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5
Q

tx trichomoniasis

A

metronidazole

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6
Q

family of metronidazole and mechanism

A

tinidazole
(anaerobic and parasitic)
disrupts DNA 3ary structure

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7
Q

tx for amiebiasis

luminal amebicides

A

metronidazole
iodoqionol [queen iodos tomb]
paromomycin [pair of mice]

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8
Q

tx amebiasis

systemic amebicides

A

emetine

dehydroemetine

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9
Q

tx for toxoplasmosis

A

pyrimethamine [pyramid shaped eggs],
sulfadiazine [sulfa dyed eggs] - s
atoquavone -

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10
Q

mechanism nifurtimox

A

T. cruzi

  • produces intracellular free radicals that kill organism *
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11
Q

miltefosine

mech

A

leishmaniasis

- bind to parasitic dna

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12
Q

metronidazole

mech

A

giardia
amebiasis
trichomoniasis
- bind to protein and dna

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13
Q

quacrine

mech

A

giardia

-binds to membrane phospholipids

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14
Q

systemic amebicides mech

Contraindicated

A

emetine
dehydroemetine

block chain elongation of proteins

Contraindicated in pregnancy cause cardiotoxicity

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15
Q

pyrimethamine
sulfadiazine
mech

A

toxoplasmosis

  • inhibits folate synthesis
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16
Q

atovaquone

mech

A

toxoplasmosis
PCP
- inhibits mitochondrial ETC

17
Q

tx PCP

A

TMP SMZ* best one
pentamidne
atovaquone
dapsone— in AIDS patients

18
Q

malaria

drug of choice for which one

A

plasmodium falcifarum- primaquine

vivax, ovale, malarial– chloroquine quinine

19
Q

malaria tx

erythricytic cycke

A 
slow
-cloroquine
-quinidine
-mefloquine
fast
- proguanil
- pyrimethamine
20
Q

malaria tx

exoerythocrytic stage

A

chloroguanide (proquanil)

or pyrimethamine

21
Q

quinine mechanism

A

used for resistant strains of malaria

affects dna synthesis

22
Q

effects quinine

A

Cinchonism: hearing visual cna

over dose abortion

23
Q

chloroguanide (proguanil)

mechanism

A

malaria
inhibits DHF reducatase
used with chloroquine in prophylaxis

24
Q

artemether

mechanism

A

inhibits DNA and protein synthesis

Was found in worm wood

25
Q

best tx for malaria

A

combination of atovaquone and proguanil

26
Q

tx for nematodes

A

roundworms

mebendazole

27
Q

mechanism for mebendazole

A

inhibits microtubule synthesis of parasite

ascaris, enterobius, necator, ancylostoma, trichuris

28
Q

tx for filariasis

A

wurcheria bancrofti

diethylcarbamazine

29
Q

tx for flatworms

A

praziquantel

niclosamide

30
Q

tx for trematodes and cestodes

A

praziquantel

31
Q

mechanism of praziquantel

A

increases calcium permeability and paralyses worm musculature

32
Q

Mechanism

Melasoprostol

A

T. Brucei

Inhibits parasitic enzymes by binding to sulfhydril groups

33
Q

Proguanil and pyrimethamine

Mech

A

Inhibit plasmodial dihydrofolate reductase

34
Q

Primaquine

Mech

A

Malaria
Inhibits plasmodial dna replication
One that’s used in relapses in p vivax and ovale

35
Q

Praziquantel CI

A

in cysticercosis of eye

Can damage eye

Pharmacology Final (20 decks)

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