Anti Parasitics Flashcards
tx tripanosoma gambiencie/ brucei
suramin
melasoprostol
pentamidine
tx trypanosoma cruzi
nifurtimox [knee high fur socks]
tx Leishmaniasis
stibogluconate [t bone steak]
miltefosine-
tx of giarda
metronidazole
quacrine-
tx trichomoniasis
metronidazole
family of metronidazole and mechanism
tinidazole
(anaerobic and parasitic)
disrupts DNA 3ary structure
tx for amiebiasis
luminal amebicides
metronidazole
iodoqionol [queen iodos tomb]
paromomycin [pair of mice]
tx amebiasis
systemic amebicides
emetine
dehydroemetine
tx for toxoplasmosis
pyrimethamine [pyramid shaped eggs],
sulfadiazine [sulfa dyed eggs] - s
atoquavone -
mechanism nifurtimox
T. cruzi
- produces intracellular free radicals that kill organism *
miltefosine
mech
leishmaniasis
- bind to parasitic dna
metronidazole
mech
giardia
amebiasis
trichomoniasis
- bind to protein and dna
quacrine
mech
giardia
-binds to membrane phospholipids
systemic amebicides mech
Contraindicated
emetine
dehydroemetine
block chain elongation of proteins
Contraindicated in pregnancy cause cardiotoxicity
pyrimethamine
sulfadiazine
mech
toxoplasmosis
- inhibits folate synthesis
atovaquone
mech
toxoplasmosis
PCP
- inhibits mitochondrial ETC
tx PCP
TMP SMZ* best one
pentamidne
atovaquone
dapsone— in AIDS patients
malaria
drug of choice for which one
plasmodium falcifarum- primaquine
vivax, ovale, malarial– chloroquine quinine
malaria tx
erythricytic cycke
slow -cloroquine -quinidine -mefloquine fast - proguanil - pyrimethamine
malaria tx
exoerythocrytic stage
chloroguanide (proquanil)
or pyrimethamine
quinine mechanism
used for resistant strains of malaria
affects dna synthesis
effects quinine
Cinchonism: hearing visual cna
over dose abortion
chloroguanide (proguanil)
mechanism
malaria
inhibits DHF reducatase
used with chloroquine in prophylaxis
artemether
mechanism
inhibits DNA and protein synthesis
Was found in worm wood
best tx for malaria
combination of atovaquone and proguanil
tx for nematodes
roundworms
mebendazole
mechanism for mebendazole
inhibits microtubule synthesis of parasite
ascaris, enterobius, necator, ancylostoma, trichuris
tx for filariasis
wurcheria bancrofti
diethylcarbamazine
tx for flatworms
praziquantel
niclosamide
tx for trematodes and cestodes
praziquantel
mechanism of praziquantel
increases calcium permeability and paralyses worm musculature
Mechanism
Melasoprostol
T. Brucei
Inhibits parasitic enzymes by binding to sulfhydril groups
Proguanil and pyrimethamine
Mech
Inhibit plasmodial dihydrofolate reductase
Primaquine
Mech
Malaria
Inhibits plasmodial dna replication
One that’s used in relapses in p vivax and ovale
Praziquantel CI
in cysticercosis of eye
Can damage eye
