Sulfasalazine Flashcards
1
Q
What is it?
A
a disease modifying anti-rheumatic drug (DMARDs) used in the management of inflammatory arthritis, especially rheumatoid arthritis. It is also used in the management of inflammatory bowel disease.
2
Q
MOA
A
a prodrug for 5-ASA which works through decreasing neutrophil chemotaxis alongside suppressing proliferation of lymphocytes and pro-inflammatory cytokines.
3
Q
Cautions
A
G6PD deficiency
allergy to aspirin or sulphonamides (cross-sensitivity)
4
Q
adverse effects
A
oligospermia
Stevens-Johnson syndrome
pneumonitis / lung fibrosis
myelosuppression, Heinz body anaemia, megaloblastic anaemia
may colour tears → stained contact lenses
5
Q
pregnancy
A
safe
6
Q
breastfeeding
A
safe
