HYPERSENSITIVITIES Flashcards

1
Q

What is type I hypersensitivity reaction?

A

anaphylactic

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2
Q

mechanism of type I

A

IgE binds to mast cells

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3
Q

examples of Type I

A

anaphylaxis

atopy

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4
Q

type II - what is it?

A

cell bound

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5
Q

mechanism of type II

A

IgG or IGM binds to antigen on cell surface

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6
Q

examples of Type II

A
  • Autoimmune haemolytic anaemia
  • ITP
  • Goodpasture’s syndrome
  • Pernicious anaemia
  • Acute haemolytic transfusion reactions
  • Rheumatic fever
  • Pemphigus vulgaris / bullous pemphigoid
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7
Q

type III - what is

A

immune complex

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8
Q

mechanism of type III

A

free antigen and antibody (IgG, IgA) combine

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9
Q

examples of type III

A
  • Serum sickness
  • Systemic lupus erythematosus
  • Post-streptococcal glomerulonephritis
  • Extrinsic allergic alveolitis (especially acute phase)
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10
Q

type IV - what is it

A

Delayed hypersensitivity

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11
Q

mechanism of type IV

A

t-cel mediated

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12
Q

examples of type IV

A
  • Tuberculosis / tuberculin skin reaction
  • Graft versus host disease
  • Allergic contact dermatitis
  • Scabies
  • Extrinsic allergic alveolitis (especially chronic phase)
  • Multiple sclerosis
  • Guillain-Barre syndrome
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13
Q

type V mechanism

A

antibodies that recognise and bind to the cell surface receptors.

This either stimulating them or blocking ligand binding

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14
Q

examples

A

Graves’ disease

Myasthenia gravis

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