AZATHIOPRINE Flashcards
1
Q
What is it?
A
Azathioprine is metabolised to the active compound mercaptopurine, a purine analogue that inhibits purine synthesis.
2
Q
What needs to be looked for in individuals?
A
thiopurine methyltransferase (TPMT) test may be needed to look for individuals prone to azathioprine toxicity.
3
Q
adverse effects
A
bone marrow depression
n+v
pancreatitis
increased risk of non-melanoma skin cancer
4
Q
inertactions
A
allopurinol
5
Q
pregnancy safe?
A
yes
