BONE TUMOURS Flashcards

1
Q

What is an osetoma?

A

benign ‘overgrowth’ of bone, most typically occuring on the skull

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2
Q

What is an osetoma associated with?

A

Gardner’s syndrome (a variant of familial adenomatous polyposis, FAP)

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3
Q

What is an osteochondroma/exotosis?

A

MOST COMMON benign bone tumour

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4
Q

epidemiology of osteochondroma

A

males

patients <20 yrs

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5
Q

features of osetochondroma/extosis

A

cartilage-capped bony projection on the external surface of a bone

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6
Q

what is a giant cell tumour

A

tumour of multinucleated giant cells within a fibrous stroma

benign

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7
Q

epidemiology of giant cell tumour

A

20-40 years

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8
Q

where does the giant cell tumour occur?

A

epiphyses of long bones

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9
Q

what does X-ray show in giant cel tumour

A

double bubble

soap bubble

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10
Q

what are examples of benign bone tumours

A
  1. osetoma
  2. osteochondroma
  3. giant cel tumour
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11
Q

What is an osteosarcoma?

A

most common primary malignant bone tumour

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12
Q

types of malignant tumours

A

osteosarcoma

ewings sarcoma

chrondrosarcoma

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13
Q

who is an osteosarcoma most commonly seen in?

A

children and adolescents

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14
Q

where does an osteosarcoma tend to occur in the body?

A

metaphyseal region of long bones prior to epiphyseal closure, with 40% occuring in the femur, 20% in the tibia, and 10% in the humerus

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15
Q

what does xray show in osteosarcoma

A

codman triangle - from periosetal elevation and sunburst pattern

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16
Q

what mutation increases risk of osteosarcoma and what condition is it associated with

A

mutation of Rb gene - retinoblastoma

17
Q

what are the other predisposing factors of osteosarcoma

A

Paget’s disease

radiotherapy

18
Q

what is Ewings sarcoma

A

small round blue cell tumour

19
Q

who is Ewings sarcoma seen in

A

children and adolescents

20
Q

where does Ewings sarcoma occur

A

pelvis and long bones. Tends to cause severe pain

21
Q

what thrombosis translocation is it associated with and what gene product

A

t(11;22) translocation which results in an EWS-FLI1

22
Q

what does the xray show

A

onion skin appearance

23
Q

what is chondrosarcoma?

A

malignant tumour of the cartilage

24
Q

where does chondrosarcoma tend to affect?

A

axial skeleton

25
Q

who does chondrosarcoma tend to affect

A

middle aged