HLA ASSOCIATIONS Flashcards
1
Q
What are HLA antigens
A
HLA antigens are encoded for by genes on chromosome 6.
HLA A, B and C are class I antigens
whilst DP, DQ, DR are class II antigens.
2
Q
What condition is associated with HLA-A3
A
haemochromatosis
3
Q
HLA-B51
A
Bechet’s
4
Q
HLA-B27 (x3)
A
ankylosing spondylitis
reactive arthritis
acute anterior uveitis
5
Q
HLA-DQ2/DQ8
A
coeliacs disease
6
Q
HLA-DR2
A
narcolepsy
good pastures
7
Q
HLA-DR3
A
dermatitis herpetiformis
Sjogren’s syndrome
primary biliary cirrhosis
8
Q
HLA-DR4
A
T1DM - and HLA-DR3
RA
9
Q
which particular gene in regards to RA
A
DRB1 gene
