ANCA ASSOCIATED VASCULITIS

Question 1

What does ANCA stand for?

Answer 1

anti-neutrophil cytoplasmic antibodies

Question 2

what is ANCA associated with?

Answer 2

number of small-vessel vasculitides

granulomatosis with polyangiitis

eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)

microscopic polyangiitis

Question 3

features of ANCA associated vasculitis

Answer 3

1. renal impairments
2. resp symptoms
3. systemic symptoms
4. vasculitic rash
5. ent sx

Question 4

1st line Ix

Answer 4

1. urinalysis - haematuria and proteinuria
2. bloods - FBC, U&Es, CRP, ANCA
3. CXR - nodular, fibrotic or infiltrative lesions may be seen

Question 5

types of ANCA

Answer 5

cytoplasmic (cANCA) and perinuclear (pANCA).

Question 6

what is cANCA associated with?

Answer 6

granulomatosis with polyangitis

Question 7

what is pANCA associated with?

Answer 7

eosinophilic granulomatosis with polyangitis

Question 8

conditions associated with pANCA

Answer 8

Ulcerative colitis (70%)
Primary sclerosing cholangitis (70%)
Anti-GBM disease (25%)
Crohn’s disease (20%)

Question 9

can you use pANCA to measure level of disease activity?

Answer 9

no

Question 10

can you use CANCA to measure degree of disease activity?

Answer 10

Some correlation between cANCA levels and disease activity

Question 11

mx

Answer 11

specialists

biopsies - kidney or lung

immunosuppression