STS

Question 1

Most STS occur in middle-aged to older dogs with the exception of

Answer 1

rhabdomyosarcoma

Question 2

What is the likelihood of local recurrence for STS after surgery dependent on?

Answer 2

tumor size, degree of infiltration, completeness of excision, grade

Question 3

What is the likelihood of metastasis from STS primarily dependent on?

Answer 3

Grade

Question 4

What are the symptoms seen with intermuscular lipomas in dogs? (Case JAAHA 2012)

Answer 4

lameness, horner’s

Question 5

What was the rate of recurrence for marginally excised intermuscular lipomas? (Case JAAHA 2012)

Answer 5

0% during a mean follow up time of 13.5mo

Question 6

Where to 80% of intermuscular lipomas occur on the pelvic limb of dogs? (Case JAAHA 2012)

Answer 6

Between the semimembranous and semitendinousus

Question 7

What is the survival time for dogs with lymphangiosarcoma? What improves this? (Curran VCO 2014)

Answer 7

Survivals range from 60-941d

Multimodal therapy improves

Question 8

What was the DFI in dogs with incompletely resected STS treated with CTX/piroxicam vs. controls? (Elmslie JVIM 2008)

Answer 8

410d treated (13.6mo) vs. 211d (7mo) in controls

Question 9

What was the rate of SHC in dogs treated with metronomic CTX and piroxicam for incompletely excised STS? What was the dose of CTX? (Elmslie JVIM 2008)

Answer 9

SHC = 10%

CTX 10mg/m2 PO q24hrs

Question 10

What was the outcome of dogs with high grade STS treated w/ or w/o doxorubicin? (Selting JAVMA 2005)(

Answer 10

No difference - no benefit to doxo

Question 11

Neutrophil:lymphocyte in STS was (higher/lower) and albumin:globulin in STS was (higher/lower) than in dog with benign soft tissue tumors (lipomas or fibromas? (Macfarlane JSAP 2016)

What cutoffs were recommended?

Answer 11

Neut:lymph higher, alb:glob lower (think inflammation)

neut: lymph >4.5 consistent with STS
alb: glb <1 consistent with STS

Question 12

What marker was expressed in well differentiated and dedifferentiated liposarcomas (vs. not in pleomorphic liposarcomas) and was also found in grade 1 liposarcomas? (Avallone Vet Path 2016)

Answer 12

MDM2

Question 13

Hemangiopericytomas had higher _____ compared to PNST (de Queiroz VCO 2012)

Answer 13

serum VEGF

Question 14

What is prognostic for tumor recurrence for STS? (Dennis Vet Path 2011)

Answer 14

Complete margins predicts nonrecurrence

propensity for recurrence increases with tumor grade

Question 15

What does and what does not correlated with reduced survival time for dogs with STS?

Answer 15

High mitotic index prognostic for survival (> 9 = 150-343d, <9 826-1138d)

Metastasis did not equate with poor survival

Question 16

What was the rate of recurrence for marginally or narrowly excised grade I II or III STS? (Dennis Vet Path 2011)

Answer 16

I 7% recurrence

II - 35% recurrence

III - 75% recurrence

Question 17

A size of ____ was prognostic for mass recurrence in perivascular wall tumors (Stefanello JVIM 2011)

Answer 17

> 5cm

Question 18

What was the MST for dogs twith trigeminal nerve sheath tumors treated with hypofractionated frameless volumetric modulated arc RT? (Dolera VRU 2018)

Answer 18

MST 952 d (31.7mo = 2.6yrs)

Question 19

What were the most common clinical signs for dogs with trigeminal nerve sheath tumors? (Swift VRU 2017)

Answer 19

masticatory mm atrophy (26/27 dogs, usually unilateral)

neuro signs related to intracranial disease (48%)

ocular disease (85%)

Question 20

What was the MST for dogs with trigeminal nerve sheath tumors treated with SRT vs. no treatment? (Swift VRU

Answer 20

SRT 441d (14.7mo)

no treatment 12 d (but wide range)

Question 21

What was the rate of clinical benefit for dogs with macroscopic sts treated with 5x6gy RT? (Cancedda VRU 2016)

Answer 21

100% clinical benefit

10% CR, 20% PR, 70%SD

Question 22

Did the addition of metronomic chemotherapy improve survival times for dogs with macroscopic STS treated with 5 x 6gy RT? What was the metronomic chemo protocol? (Cancedda VRU 2016)

Answer 22

Metronomic = thalidomide 1-2mg/kg/day, piroxicam 0.3mg/kg/day, CTX 7mg/m2 EOD

OST longer (757 vs. 286) but PFI was not

Question 23

What was the rate of local recurrence and metastasis for dogs with microscopic STS treated with hypofx rt? (6-8Gy weekly fx to 24-32Gy) (Kung VCO 2014)

Answer 23

21% local recurrence, 23% met rate

Question 24

What is the MST for dogs with splenic liposarcoma treated with surgery? What was prognostic? (Gower JAVMA 2015)

Answer 24

MST 623

Mets = shorter MST (45d)

Grade prognostic

Grade 1 >1009d, grade 2 = 206d, grade 3 = 74d

Question 25

What was the overall rate of metastasis for dogs treated for primary abdominal visceral STS? What was correlated with likelihood of mets? (Linden VCO 2019)

Answer 25

overall 40%, 30% at surgery

grade correlated - 20% grade I, 27% gr2, 60%gr 3

Question 26

A mitotic index of ____ was associated with survival post-op for primary abdominal visceral STS in dogs (Linden VCO 2019)

Answer 26

MI ≥ 9 = 269d

MI < 9 = MST not reached