STS Flashcards
Most STS occur in middle-aged to older dogs with the exception of
rhabdomyosarcoma
What is the likelihood of local recurrence for STS after surgery dependent on?
tumor size, degree of infiltration, completeness of excision, grade
What is the likelihood of metastasis from STS primarily dependent on?
Grade
What are the symptoms seen with intermuscular lipomas in dogs? (Case JAAHA 2012)
lameness, horner’s
What was the rate of recurrence for marginally excised intermuscular lipomas? (Case JAAHA 2012)
0% during a mean follow up time of 13.5mo
Where to 80% of intermuscular lipomas occur on the pelvic limb of dogs? (Case JAAHA 2012)
Between the semimembranous and semitendinousus
What is the survival time for dogs with lymphangiosarcoma? What improves this? (Curran VCO 2014)
Survivals range from 60-941d
Multimodal therapy improves
What was the DFI in dogs with incompletely resected STS treated with CTX/piroxicam vs. controls? (Elmslie JVIM 2008)
410d treated (13.6mo) vs. 211d (7mo) in controls
What was the rate of SHC in dogs treated with metronomic CTX and piroxicam for incompletely excised STS? What was the dose of CTX? (Elmslie JVIM 2008)
SHC = 10%
CTX 10mg/m2 PO q24hrs
What was the outcome of dogs with high grade STS treated w/ or w/o doxorubicin? (Selting JAVMA 2005)(
No difference - no benefit to doxo
Neutrophil:lymphocyte in STS was (higher/lower) and albumin:globulin in STS was (higher/lower) than in dog with benign soft tissue tumors (lipomas or fibromas? (Macfarlane JSAP 2016)
What cutoffs were recommended?
Neut:lymph higher, alb:glob lower (think inflammation)
neut: lymph >4.5 consistent with STS
alb: glb <1 consistent with STS
What marker was expressed in well differentiated and dedifferentiated liposarcomas (vs. not in pleomorphic liposarcomas) and was also found in grade 1 liposarcomas? (Avallone Vet Path 2016)
MDM2
Hemangiopericytomas had higher _____ compared to PNST (de Queiroz VCO 2012)
serum VEGF
What is prognostic for tumor recurrence for STS? (Dennis Vet Path 2011)
Complete margins predicts nonrecurrence
propensity for recurrence increases with tumor grade
What does and what does not correlated with reduced survival time for dogs with STS?
High mitotic index prognostic for survival (> 9 = 150-343d, <9 826-1138d)
Metastasis did not equate with poor survival
What was the rate of recurrence for marginally or narrowly excised grade I II or III STS? (Dennis Vet Path 2011)
I 7% recurrence
II - 35% recurrence
III - 75% recurrence
A size of ____ was prognostic for mass recurrence in perivascular wall tumors (Stefanello JVIM 2011)
> 5cm
What was the MST for dogs twith trigeminal nerve sheath tumors treated with hypofractionated frameless volumetric modulated arc RT? (Dolera VRU 2018)
MST 952 d (31.7mo = 2.6yrs)
What were the most common clinical signs for dogs with trigeminal nerve sheath tumors? (Swift VRU 2017)
masticatory mm atrophy (26/27 dogs, usually unilateral)
neuro signs related to intracranial disease (48%)
ocular disease (85%)
What was the MST for dogs with trigeminal nerve sheath tumors treated with SRT vs. no treatment? (Swift VRU
SRT 441d (14.7mo)
no treatment 12 d (but wide range)
What was the rate of clinical benefit for dogs with macroscopic sts treated with 5x6gy RT? (Cancedda VRU 2016)
100% clinical benefit
10% CR, 20% PR, 70%SD
Did the addition of metronomic chemotherapy improve survival times for dogs with macroscopic STS treated with 5 x 6gy RT? What was the metronomic chemo protocol? (Cancedda VRU 2016)
Metronomic = thalidomide 1-2mg/kg/day, piroxicam 0.3mg/kg/day, CTX 7mg/m2 EOD
OST longer (757 vs. 286) but PFI was not
What was the rate of local recurrence and metastasis for dogs with microscopic STS treated with hypofx rt? (6-8Gy weekly fx to 24-32Gy) (Kung VCO 2014)
21% local recurrence, 23% met rate
What is the MST for dogs with splenic liposarcoma treated with surgery? What was prognostic? (Gower JAVMA 2015)
MST 623
Mets = shorter MST (45d)
Grade prognostic
Grade 1 >1009d, grade 2 = 206d, grade 3 = 74d
What was the overall rate of metastasis for dogs treated for primary abdominal visceral STS? What was correlated with likelihood of mets? (Linden VCO 2019)
overall 40%, 30% at surgery
grade correlated - 20% grade I, 27% gr2, 60%gr 3
A mitotic index of ____ was associated with survival post-op for primary abdominal visceral STS in dogs (Linden VCO 2019)
MI ≥ 9 = 269d
MI < 9 = MST not reached
