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Oncology Boards > LSA - Canine, non-chemo > Flashcards

LSA - Canine, non-chemo Flashcards

1
Q

Prevalence of anemia was (higher/lower) in dogs with LSA vs. IBD and what # of RBC anomalies per dog was able to differentiate b/w LSA and IBD with 71% sens and 70% spec. (Parachini-Winter JAVMA 2019)

A

LSA = higher rate of anemia (53% vs. 22% of IBD)

3+ different RBC anomalies = more likely to be LSA, eccentrocytes most common single finding in LSA

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2
Q

What was the relationship between serum thymidine kinase 1 (STK1) and LSA response/relapse in dogs? (Boye JVIM 2019)

A

Pretreatment sTK1> 20Du/L in 88% of dogs, significantly lower in dogs that had CR vs PR

Dogs that had CR with 5x increase in sTK1 at 4wk interval predicted replase at nexd recheck (sens 50%, spec 94%)

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3
Q

What was the expression profile of PTEN and the MTOR-PI3K-AKT axis in CD4+ T cell nodal LSA in dogs? (Harris VCO 2019)

A

Downregulation of PTEN

Upregulation of MTOR-PI3K-AKT axis

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4
Q

What was the relationship bewtween the s-phase fraction of canine LSA measured by flow with the grade of the LSA? (Miniscalco J comp Path 2018)

A

Higher % in high grade B or T cell LSA vs. low grade

cutoff value of 3.15% best in discriminating b/w the two

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5
Q

S-phase fraction of LSA in dogs was correlated with what other value measured by flow? (Miniscalco J Comp Path 2018)

A

Strongly correlated with Ki67

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6
Q

What was the cytologic/histologic agreement b/w endoscopic bx for LSA vs. enteritis in dogs? Specificity and sensitivity? (Maeda Vet Path 2017)

A

81.4% (136/167 cases)

Spec 73.5%, sens 98.6%

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7
Q

What was the CT appearance of the liver/spleen in the majority of dogs with multicentric LSA w/ cytologic evidence of splenic/hepatic involvement? (Jonse JSAP 2017)

A

Normal

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8
Q

What MRI phases were the most useful in identifying LSA in the spine of dogs? (Allett VRU 2016)

A

STIR and T1 post-contrast

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9
Q

In dogs with multicentric LSA, addition of cytology to splenic and hepatic ultrasound, a significant shift ocurred from what stage to what stage? What did this study confirm about stage and prognosis in dogs with LSA? (Nerschbach VCO 2016)

A

Significant shift from stage IV to III

Confirmed no change in outcome for stage III vs. IV

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10
Q

What was found when the intraclass correlation coefficient (ICC) was measured between clinicians for measuring LN size and % change in dogs with LSA? (Childress VCO 2016)

A

Some variation between inter-rater reliability for LN measurement, but high ICC for % change in LNs (0.94 for sum LD)

–> inter-and intra-rater reliability in measurements among the 3 raters = good to excellent

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11
Q

Loss of what can be observed in Boxers and may be why they tend to get T cell LSA (Pawlak VCO 2016)

A

canine chromosome 11

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12
Q

What was found regarding FoxP3 IHC positivity in samples from dogs with IBD vs. small cell LSA? What about IL-10? (Maeda Vet Path 2015)

A

FoxP3+ and IL-10 significantly lower in IBD compared to healthy and LSA

FoxP3+ higher in LSA

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13
Q

What were the blood levels used in the “canine lymphoma blood test” (cLBT) and how did they correlated with remission/relapse? (Alexandrakis VCO 2014)

A

C reactive protein and haptoglobin

cBLT levels correlated well with how clinican assessed remission/relapse

Dogs with the lowest cBLT scores at their remission showed the longest survival times

Pretreatment levels correlated with outcome

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14
Q

In dogs with high FoxP3 expression and small SI LSA, what was found to b ecorrelated with a worse prognosis? (Maeda Vet Path 2015)

A

Higher numbers of Tregs

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15
Q

Dog with non-focal hematopoietic neoplasia were able to be distinguished from normal dogs based on what on MRI? (Feeney Comp Med 2013) **committee member**

A

Visual and ROI (region of interest) signal intensity relationships to skeletal mm on T2

Take home: MR may be useful in distinguishing normal from abnormal in these dogs based on visual and ROI comparisons b/w organs/tissues

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16
Q

What phenotype are most canine intestinal LSAs? (Ohmura VCO 2015, Kaneko J Vet Med Sci 2008)

A

T cell

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17
Q

What was the association of AgNOR/cell and Ki67 positivity between dogs with LSA vs. lymphadenitis, hyperplasia or normal LN? (Bauer JVIM 2007)

A

Higher in LSA

>2.04 AgNOR/cell 95% spec/sens for LSA

Ki67+ >10.4% 95% sens/98%spec for LSA

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18
Q

What level of MHCII expression is associated with a worse outcome in dogs with B cell LSA? What other patient/disease characteristics were associated with outcome? (Rao JVIM 2011)

A

Low MHCII = worse prognosis: 120d (4mo) vs 314d (10.5mo)

Cell size (large 155d vs. small 275d) and patient age (<7yr) associated with mortality

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19
Q

Survivin expression level in dogs with LSA was correlated with what? (Rebhun JVIM 2008)

A

High survivin immunoreactivity = shorter median DFI: 171d (5.7mo) vs. 321d (10.7mo)

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20
Q

What is considered the minimum measurable disease for dogs with peripheral nodal LSA and at least one lesion of what size is needed to evaluate response to treatment? (VCO Vail 2010 (VCOG))

A

10mm = minimum for measurable disease

one lesion needs to be at least 20mm - if target lesion becomes <10mm, considered non measurable but still record actual measurement or if can’t be measured default = 5mm

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21
Q

What is the requirement for a new lesion to count as PD under VCOG? (Vail VCO 2010)

A

Any new lesion that is peripheral and >15mm

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22
Q

What is the definition of PD for dogs with LSA under VCOG? (Vail VCO 2010)

A

PD = 20% increase in mean sum LD from smallest mean sum

The LD of at least one of the target lesions must demonstrate an absolute increase of at least 5 mm compared with its nadir for PD to be defined. For target lesions <10 mm at nadir, an increase in LD of any single previously identified target lesion to ≥15 mm

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23
Q

PFS, PFS-rate, OS, event-free survival, TTP and LSA-specific survival all a measured from ____ whereas disease-free survival and response duration are measured from _____ (VCOG, Vail VCO 2010)

A

PFS, PFS-rate, OS, event-free survival, TTP and LSA-specific survival: measured from initiation of treatment

disease-free survival and response duration: documentation of response

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24
Q

What flow characteristics of T cell LSA are associated with indolent T cell LSA vs. high grade T cell LSA? (Avery JVIM 2014)

A

indolent: CD45-, high MHCII (MST not reached)

High grade: CD45+ and low MHC II (MST 159d/5.3mo)

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25
Q

What TCR-gamma rearrangements were most common in dogs with T cell LSA? (Keller Vet Immuno 2012)

A

V-gamma-2, -3 and -7

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26
Q

What was the relationship found between serum thymidine kinase and LSA in dogs? (von Euler JVIM 2004)

A

Higher TK activity in dogs w/ LSA (>7U/L)

TK 3wks prior to and at the time of relapse sig higher than at remission

Dogs with TK >30 U/L had shorter survival times

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27
Q

Dogs imaged with PET/CT were found to have decreases in what PET marker after treatment which correlated with Ki67 levels in 43% of the dogs in the study (Lawrence VRU 2009)

A

18F-fluorothymidine (FLT) (proliferation marker)

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28
Q

What factors were associated with a PR (rather than CR) in dogs with ndoal DLBCL treated with CHOP? What about lower PFS? (Childress VCO 2018)

A

PR: Thrombocytopenia, older patient, high globulins

Lower PFS: thrombocytopenia, neutrophilia, olderpatient

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29
Q

What was the presentation for dogs with nodal marginal zone LSA? (Cozzi VCO 2018)

A

1/3 systemically ill, stage V in all

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30
Q

What was the response and outcome for dogs with nodal marginal zone LSA? (Cozzi VCO 2018)

A

Outcome poor despite “indolent” designation

Treatment with chemo or chemo-immunotherapy: 73% RR

TTP 149d, LSA-specific survial 259d

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31
Q

What was te clinical presentation for dogs with TZL of the tongue? Response to therapy? (Harris VCO 2018) **committee member**

A

11/12 dogs had lymphocytosis and or LN involvement

Various treatments, 7/12 CR, 4/12 SD

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32
Q

What population of lymphocytes has been found in older golden retrievers? (Hughs VCO 2018)

A

CD45 negative T cells (T zone cells) both in dogs w/ and w/o TZL

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33
Q

What was the PFS for dogs with high-grade primary mediastinal treated with CHOP vs overall PFS and OS? What was associated with better OS?

A

CHOP: PFS 144d, OS 194d

Overall: PFS 133d, OS 183d

absence of pleural effusion at dx aossc’ w/ better OS (but not PFS)

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34
Q

What locations of T cell LSA were associated with shorter survival? What about shorter PFI? (Deravi Vet Immuno 2017)

A

survival: GI, multicentric + concurrent leukemia

PFI: GI, hepatosplenic

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35
Q

For dogs with multicentric T cell LSA, which phenotype had the shortest survival time? What phenotypes did better? (Deravi Vet Immuno 2017)

A

Shortest: CD4+/CD8-/MHCII-

Longer: CD4+/CD8-/MHCII+; CD4-/CD8+/MHCII + or -

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36
Q

What was the more common immunophenotype for dogs with low-grade gastrointestinal LSA? What was the response to treatment (2/20 had sx, all dogs had chemo, usually pred/chlorambucil) (Lane JSAP 2017) **Committee Member**

A

Most T-cell (95%)

ORR 70%, MST 424d (14.1mo)

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37
Q

What are mott cells? (Stacy Vet Clin Path 2008)

A

B cell lymphocytes that accumulate large amounts of nonsecreted immunoglobulin (Russel bodies)

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38
Q

What phenotype is characteristic of Tzone LSA? (Seelig JVIM 2014)

A

CD 45- T-cell (T cell based on CD3 or CD5 +)

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39
Q

What is the most common WHO classification of canine LSA? What are the subtypes? (Valli Vet Path 2011)

A

diffuse large B cell LSA (DLBCL) - all CD79a+

Centroblastic, immunoblastic, T cell rich DLBCL

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40
Q

Describe the characteristic histo findings for centroblastic canine DLBCL (Valli Vet Path 2011)

A

Multiple nucleoli at nuclear periphery

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41
Q

Describe the characteristic histo findings for Immunoblastic canine DLBCL (Valli Vet Path 2011)

A

Single prominent central nucleolus

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42
Q

Describe the characteristic histo findings for T cell rich DLBCL (Valli Vet Path 2011)​

A

neoplastic B cells amid predominant population of nonneoplastic T cells

43
Q

What is the most common primary lymphoma of the spleen? (Valli Vet path 2011)

A

Marginal zone LSA

44
Q

What WHO classification of lymphoma is the most aggressive lymphoma in dogs? (Valli Vet Path 2011)

A

T cell lymphoblastic lymphoma (T-LBL)

45
Q

What is IHC pattern is characteristic of T-zone LSA? (Valli Vet Path 2011)

A

Nodal T cell LSA (CD3+) in which neoplastic cells excpand the paracortex and medullary cords but do not efface architecture

46
Q

Hepatosplenic LSA in dogs likely originates from what cells? Prognosis? (Keller Vet Path 2013)

A

CD11d+ gamma-delta T cells of splenic red pulp

(CD 3+, TCR gamma-delta +, CD11d+)

Prognosis terrible - all but 1/7 died w/in 24d

47
Q

What immunophenotype is associated with heptocytotrophic LSA in dogs? What lab findings are also associated? (Keller Vet Path 2013)

A

CD11d- phenotype –> not from splenic pulp gamma/delta T cells (like hepatosplenic LSA)

Marked cholestasis; also thrombocytopenia, hypoproteinemia, mild to absent anemia

Still aggressive

48
Q

What retinoid receptors were expressed in dogs with cLSA? (Souza JVIM 2010)

A

RAR beta in 87%

RXR alpha and gamma in 77%

49
Q

What form of T cell LSA is most common in Boxers? (Lurie Vet Immuno 2008)

A

TCRalpha/beta+, CD4+ with lymphoblastic morphology

50
Q

What three major groups of LSA were defined by expression profiles (Frantz and Modiano Vet Path 2012)

A

1. Low grade T cell = T zone LSA

2. High grade T cell = lymphoblastic T cell and PTCL-NOS (NOS=not otherwise specified)

3. B cell = marginal, diffuse, Burkitt LSA

51
Q

What gene profile was used to classify LSA into B cell vs. T cell (Frantz and Modiano Vet Path 2012)

A

T cell = CD28/ABCA5 > 1

B cell = CD28/ABCA5 <1

52
Q

What gene profile was used to classify T cell LSA as high or low grade?

A

Ratio of CCDC3 and SMOC2

> 1 = low grade

< 1 = high grade

53
Q

What is the recommended treatment for splenic marginal zone LSA? Why? (Stefanello JVIM 2011)

A

Splenectomy

3/5 dogs died of not LSA 760, 939 and 1825d (4/5 had splenectomy + doxo), 1 dog still alive at 445d

54
Q

In dogs, what cytokines were significantly higher in dogs with LSA vs healthy dogs? Which was higher in T cell compared to B cell? (Calvalido Vet Immuno 2016)

A

MCP-1 (monocyte chemoattractant protein-1) IL-6, IL-10

IL-6 sig higher in T cell vs. B cell

55
Q

Dogs with LSA treated with tumour angitgen-coated microbeads +/- SQ IL-2 +/- GM-CSF had what type of hypersensitivity indicating which form of immunity? (Henson VCO 2010)

A

Delayed hypersensitibvity reactions to intradermal challenge, suggests specific cell-mediated immunity

56
Q

How did the number of Tregs compare in dogs with LSA when they were in remission vs. pretreatment? (Mitchell Vet Immuno 2012)

A

Circulating Treg numbers significantly decreased in remission compared to pretreatment

57
Q

What was the median lymphoma specific survival in dogs treated with 20wk chemo (l-spar, vinc, ctx, dox, ccnu, pred) alone vs. chemo + HSPCC- hydroxylapatite vaccine? (marconato Clin Cancer Res 2014)

A

505d (16.8mo) for chemo + vx vs. 159d (5.3mo) for chemo alone

(HSPCC-hydroxylapatite = Heat shock proteins (HSP) bind the small peptides they chaperone (HSPPC), allowing for immunization of the host against a large repertoire of tumor-associated antigens. Hydroxylapatite vehicles HSPPCs and acts as an immunologic adjuvant.)

58
Q

What does CD-5083 inhibit and what cancer has it been investigated in? (Gareau VCO 2018)

A

Inhibits valosin-containing protein (which maintains protein homeostasis)

LSA cell lines - disrupted ubiquitin-dependent protein degradation system, induced apoptosis via caspase cascade

59
Q

Dogs with B cell LSA that had hypermethylation of death associated protein kinase (DAPK) had what PFS and OS after CHOP chemotherapy vs. those without DAPK hypermethylation? (Sato VCO 2018)

A

Hypermethylated DAPK = shorter times - PFS 220d (7.3mo) OS 266d 8.9mo) vs w/o PFS 301d (10mo) and OS 412d (13.7mo)

60
Q

What level of CD44 isoform expression was associated with a better prognosis (high vs low) in dogs with B cell LSA? Specific exons associated with prognosis? (Motegi AJVR 2018)

A

High CD44 isoform expression = lower ORR, MPFS and mOST

High expression of exons 3, 6 & 7 = poor prognosis

61
Q

In dogs with B cells LSA, what markers did cancer stem cells (CSCs) have significantly increased expression of compared to normal LN (Hartley VCO2019)

A

CD34+, CD90+, CD117+, Oct 3/4+

62
Q

In dogs with T cells LSA, what markers did cancer stem cells (CSCs) have significantly increased expression of compared to normal LN (Hartley VCO2019)

A

Oct3/4+

63
Q

What were the characteristics of LSA cells selected for resistance to CHOP from the study looking at CSC markers in canine LSA? (Hartley VCO 2019)

A

Significantly upregulated expression of CSC markers

Formed spheroids in culture more readily

Expressed sig. greated aldehyde dehydrogenase activity

(compared to chemo-sensitive tumor cells)

64
Q

What was found to be significantly higher in fecal samples from dogs w/ LSA compared to control dogs? (Gavazza VCO 2018)

A

Streptococcus spp higher + high dysbiosis index in dogs with LSA

65
Q

Bcl-2/Bax ratio was higher in dogs with (B or T) cell LSA and was associated with what prognosis and other cancer features? (Meichner JVIM 2016)

A

Higher ratios: T cell LSA, shorter PFS, worse prognosis, altered apoptosis and chemotherapy resistance

66
Q

What is the human anti-CD20 mAb and can it bind to canine CD20? (Jubala Vet Path 2005)

A

Rituximab, does not bind canine CD20

67
Q

How was minimal residual disease (MRD) detected in dogs with high grade B cell LSA and how did MRD correlated with dogs remission status? (Sato JVIM 2011)

A

MRD in PBMCs measured by real time PCR - amplify rearranged Ig Heavy chain

Increase in MRD defined as greater than 0.5 on log scale

Increase in MRD 2 wks or more before relapse detected in 14/15 dogs

68
Q

What may be a sensitive marker detected in either cytologic or histo samples of LSA to differentiate between low and high grade LSA in dogs? (Vajdovich Vet Path 2014)

A

AgNOR

69
Q

How were baseline pretreatment IFN gamma tissue RNA levels related to outcome in dogs with NHL? What other cytokine was found to be significantly increased in NHL? (Dias Vet I*mmuno 2019)

A

IFN gamma = favorable response to chemo + correlated with survival outcome

IL-10 sig higher in LSA

70
Q

What is pevonedistat and what did it do to canine DLBCL cells? (Assumpcao VCO 2018)

A

Pevonedistat = selective small molecule NEDD80-activating enyzme inhibitor - leads to apoptosis DNA damage and GI cell cycle arrest via inhibition of NF-kB in people

In canine DLBCL cells - reduced cell viability via G1 cell cycle arrest and apoptosis

71
Q

Dogs with DLBCL have been found to have significantly (higher/fewer) FoxP3+ cells than in reactive LN, but no relationship b/w # of these cells and cell proliferation was found is this is unrelated to _____expression (Muir J comp path 2017)

A

Significantly lower foxp3+ cells (T regs stably express FoxP3)f

Unrelated to Ki67 expression

72
Q

Pawlak et. al published the first report on using methotrexate in what canine LSA cell lines? What did methotrexate do to these cells? (Res Vet Sci 2017)

A

CLBL-1, GL-1 and CL-1

concentration-dependent inhibitory effect on proliferation of all cell lines (CL-1 most sensitive; this cell line derived from T cell LSA so MTX may have more of a role for treating this?)

73
Q

Loss of CD45 in TZL cells is thought to be due to what? (Martini Vet Immuno 2017)

A

CD45 transcript amount lower in TZL compared to controls; lack of CD45 on cell surface appears to be due to absence of gene transcription (because the CD45 DNA was present, but low levels of transcript present)

74
Q

What genes that are prognostic in humans with B cell LSA have also been shown to have associations with prognosis in dogs with B cell LSA? (Zamani-Ahmadmahmudi BMC 2017)

A

CCND1 and BIRCS5

75
Q

What is Momelotinib and what was shown when canine LSA cells were treated with it in vitro? (Lu JVIM 2017)

A

Jak1/2 inhibitor

Caused dose-dependent cell growth inhibition

decreased phsophorylation of STAT3 in a dose dependent manner

76
Q

What level of Ki67 expression measured by flow cytometry in dogs with B cell LSA treated with UW CHOP 25 was associated with the longest LSS and relapse free interval (RFI)? (Poggi VCO 2016)

A

Intermediate expression (20.1-40%)

High and low Ki67 had shorter LSS and RFI

77
Q

What markers were used to identify lymphoid progenitor cells in dogs with B cell LSA? (Ito and Modiano JVIM 2011)

A

CD34, CD117, CD133 + CD21 or CD22 B cell markers

78
Q

What was the association of peripheral blood and bone marrow infiltration in dogs with nodal marginal zone LSA and survival? (Marconato Vet J 2019)

A

blood infiltration sign. assoc. with TTP: <30% = 186d vs. >30% 43d

BM infiltrations sig assoc. with LSS: <1% = 1400d vs. 1-20% 337d vs. >20% 188d

79
Q

What % nodal infiltration of B cell LSA measured by flow was predictive for time to relapse in dogs? (Chalfon VCO 2019)

A

Looking at MRD via flow

<0.5% infiltrate mTTR not reached (shows this is prognostic for dogs at end of chemo

>0.5% mTTR 118d

Also, acellular samples mTTR 164d

80
Q

For dogs with DLBCL treated with multiagent chemo and autologous vaccine, a lymphocyte/monocyte ratio of ____ had what effect on TTP and LSS? (Marconato Vet J 2015)

A

Lymphocyte/monocyte ratio <1.2 = significantly shorter TTP and LSS

81
Q

What morphologic features of canine LSA cells has been showed to be associated with shorter remission and survival times?

A

Presence of binulceated or multinucleated cells at dx

82
Q

What was the 1-yr survival rate of dogs with splenic LSA treated with splenectomy? After this, how many dogs died from the splenic LSA? (van Stee Vet Surg 2015)

A

1yr survival 58.8%

After this, no dogs died of LSA

83
Q

What were prognostic factors identified for dogs treated with splenectomy for splenic LSA? How did chemo affect ST? (van Stee Vet Surg 2015)

A

Poor prognostic indicators: hemoabdomen, clinical signs

Good prognostic indicators: B cell (marginal and mantle most common), disease confined to spleen

Pre or post-op chemo DID NOT improve ST

84
Q

What was the median first remission time and MST in dogs treated with chemotherapy for LSA that became neutropenic vs. those that did not? (Wang Vet J 2015)

A

First remission: neutropenia 812d (27mo) vs. 219d (7.3mo)

MST: neutropenia 952d (31.7mo) vs. 282d (9.4)

85
Q

Anemia of ____ was associated with a significantly shorter survival time in dogs with LSA, but had no effect in dogs with _____(what other type of cancer) (Miller JVIM 2009)

A

<40%; no effect in dogs with OSA

86
Q

What was the MST of dogs with splenic marginal zone LSA treated with splenectomy? What was/was not associated with MST? (O’Brien JVIM 2013)

A

MST w/ splenectomy = 383d

Worse if having clinical signs (1153d w/o vs. 309d w)

LNN involvement, hemoabdomen, chemo all had NO effect on survival

87
Q

An ABCA5:CD28 of <1 is consistent with B/T cell LSA. (Frantz and Modiano Vet Path 2013)

A

B cell; if >1 then T cell

88
Q

What was the mOST for dogs treated with a variety of protocols (chemo, RT, steroids) for central nervous system LSA? (LaRue JSAP 2018)

A

171d (but range 1-1942 days…)

89
Q

What was the MST for dogs with intermediate to high grade intranasal LSA treated with RT and/or chemo? (George VRU 2016)

A

RT +/- chemo: 15mo, chemo alone 5mo

90
Q

What was the MST for dogs with low grade T cell intranasal LSA (George VRU 2016)

A

2+ yrs (only 6 dogs in study so supported use of RT but chemo has unclear role)

91
Q

What % of dogs with intranasal LSA will have extranasal involvement at some point in the disease course (either at dx or at progression) (George VRU 2016)

A

38%

background for paper says 15% have multicentric dz at dx, 15% will develop it post treatment

92
Q

What was the ORR and MST for dogs with mucocutaneous LSA treated with RT? (Berlato VCO 2011)

A

ORR 67%, MST 770d

LN involvement and CR to RT prognostic

93
Q

What breeds are more likely to get T cell LSA (Modaino cancer res 2005)

A

Boxers: 60%

Goldens: 55%

others: cavalier, aussies, shar pei, irish wolfhound, shih tzu, husky, yorkie, corgi

94
Q

What breeds are more likely to get B cell LSA? (Modiano Canc Res 2005)

A

Cockers, Bassets - both more than other dogs and all mixed breeds

Others: boder collies, dobies, rotties, scotties and standard schnauzers

95
Q

What cytogenetic abnormalities asegregate with NHL phneotype in goldens? (Modiano Cancer res 2005)

A

B cell: deletion of chromosome 14

T cell: gain of CFA 36 and CFA 15

96
Q

What was the incidence of sterile hemorrhagic cystitis in dogs treated with oral cytoxan (divided over three days) w/o furosemide? (JAVMA 2013 Best)

A

None

Historically, 10-11% get SHC when CTX given as a single dose w/o furosemide, goes down to 1-2% if furosemide is given

97
Q

What were the most common findings on AUS for dogs with renal LSA? (Taylor JSAP 2019)

A

80% bilateral renal changes

75% renomegaly

50% abdominal lymphadenopathy

98
Q

What was the ORR, mPFS and MST for dogs with presumed primary renal LSA that were treated with chemotherapy? (Taylor JSAP 2019)

A

ORR: 47.8%, all prs

mPFS 10d, MST 12d (MST higher if responded: 47d)

99
Q

What was the MST for dogs with small intestinal T-cell LSA overall vs. with treatment? What was correlated with significantly shorter STs? (Couto VCO 2018)

A

MST 279d; w/treatment 628d

Anemia and weight loss = sig shorter ST

100
Q

What was the MST for dogs with primary intestinal LSA? (Sogame JAVMA 2018)

A

MST 62d (range 1-537d)

101
Q

What factors were associated with shorter survival times (on UV analysis) in dogs with primary intestinal LSA? (Sogame JAVMA 2018)

A

Anorexia (50d vs 81d)

Spetic peritonitis at dx (33d vs 65d w/o)

tumor locations (intestinal tract only = 121d vs. int tract + LN = 57d vs. int tract + other organs 35d)

102
Q

All dogs with intraocular LSA developed what? (Wiggans JAVMA 2014)

A

Neuro signs

conjunctival better than intraocular

103
Q

What is the overall MST for dogs with rectal LSA? What about dogs treated with chemo vs. not? What phenotype are they? (van de Steen JSAP 2012)

A

overall MST = 1697d (56.6mo = 4.7yr)

Chemo: 2352d (78.4mo = 6.5yr) vs. 70d

all b cell

Oncology Boards (26 decks)

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