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Oncology Boards > Respiratory Tumors > Flashcards

Respiratory Tumors Flashcards

1
Q

What is the rate of local recurrence for nasal SCC in cats treated surgically? What is the DFI?

A

<10% recurrence, median DFI 594d for isolated, 426d for SCC in multiple locations

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2
Q

What is the MST for cats with either isolated nasal planum SCC treated with surgery or SCC in multiple locations treated with surgery?

A

isolated: 673d multiple: 530d

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3
Q

What is the median time to recurrence for dogs treated with external beam RT for nasal planum SCC?

A

2-3mo, RT not generally used

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4
Q

What was the 1-yr PFS rate for cats with nasal planum SCC treated with orthovoltage?

A

60%

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5
Q

What is the median DFI and MST for cats treated with megavoltage RT for nasal planum SCC?

A

DFI 361-916d MST 902d

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6
Q

What was the CR rate for cats treated with intralesional carbo for nasal planum SCC?

A

73%

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7
Q

MST for dogs getting SBRT for nasal tumors (3x9gy, 3x10gy, 1x20Gy) Mayer JAVMA 2019

A

338d

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8
Q

Factors associated with MST for dogs getting SBRT for nasal tumors (3x9gy, 3x10gy, 1x20Gy) Mayer JAVMA 2019

A

tumor stage (IVa worse than I, II, III), decrease in dose falloff and increase in dose heterogeneity associated with shorter survival RT dose assoc. with survival time - shorter for 3x10Gy compared to 3x9Gy (questionable relevance) no difference in histo type, but

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9
Q

AE rates for dogs getting SBRT for nasal tumors (3x9gy, 3x10gy, 1x20Gy) Mayer JAVMA 2019

A

Acute side effects: skin 26% (dry desquamation, excludes s hair loss), oral cavity (30% grade 1 or II mucositis), ocular (discharge 26%, KCS 4%) Late (>6mo) 18% developed unilateral cataract

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10
Q

**ORR and median DFI for cats treated with strontium plesiotherapy for nasal planum SCC (JFMS 2019, Berlato)**

A
  • 74% CR (22% PR, 4% PD)
  • Median DFI 780d
    • DFI of fractionated Sr90 significantly longer than single-dose Sr90
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11
Q

OST for cats treated with strontium plesiotherapy for nasal planum SCC + prognostic factors (Berlato JFMS 2018)

A

OST 1039d

Prognostic factors influence OST = early-stage disease, absence of concurrent problems, CR

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12
Q

Response in cats treated with high-dose rate brachytherapy (6x5Gy or 4x7.5Gy) and PFS/OS? (Lino JFMS 2019) for nasal planum SCC

A

Response: 72% CR, 24% PR, 2% no response

MST 316d, OS 835d

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13
Q

Prognostic factors for cats undergoing high-dose rate brachytherapy (5x6Gy or 4x7.5Gy) for treatment of nasal planum SCC

A
  • Sex (males did worse)
  • Extension of tumor onto upper lip
  • Tumor size
  • Existence of a previous therapy
  • Tumor response
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14
Q

What was the median interval b/w last RT treatment and max tumor reduction for dogs treated with hypofractionated RT for solitary unresectable pulmoary tumors (Kawabe, VRU 2019) and what were the responses?

A

56d; PR in 6, SD in 3

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15
Q

MST for dogs with solitary pulmonary carcinoma treated with hypofractionated RT (what was the protocol?) +/- surgery and/or chemotherapy? Kawabe VRU 2019

A

MST 810d

RT protocol varied: 7.0-12Gy/fraction x 4-7 fx weekly for a total of 40-50Gy

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16
Q

What was the overall MST for dogs with intranasal tumors treated with alt. carbo/dox w/ oral piroxicam? Which tumor types did better or worse? (Woodruff VCO 2019)

A

oMST = 234d (7.8mo)

sarcomas did best - MST 448d

ACA or carcinoma = 280d

TCC - 163d

SCC/anaplastic/undiff = 59d

17
Q

What % of dogs treated with alt carbo/dox + oral piroxicam for intranasal tumors had AEs? What was the rate of gr 3/4 AEs? (Woodruff VCO 2019)

A

AEs in 69% of dogs, grade 3 or 4 in 24%

18
Q

What are the most common CT appearances of nasal chondrosarcoma in dogs? (Jania JSAP 2019)

A

72% had areas of calcification (variable patterns)

ring and arch or popcorn calcification pattern most common (as is described in humans)

19
Q

What was predictive of the presence of neoplasia vs. rhinitis on CT in cats? (Nemanic VRU 2015)

A

Abnormal medial retrophar. LN hilus + mass

abnormal medial retro LN hilus + lysis

20
Q

Which of the following were found to be phosphorylated in canine nasal carcinoma and what does this suggest?:

EGFR1

VEGFR2

PDGFR-alpha

c-kit

(Hocker Res Vet Sci 2017) **Committee member**

A

EGFR1 phosphorylated in 10/16 carciomas

absence of phosphorylated RTK targets of TOC means any clinical effect of TOC occurs through alternative unidentified pathways in canine nasal carcinoma

alsdo EGFR1 may be a therapeutic target

21
Q

Cats with what marker were more likely to achieve a CR or PR and have a significantly longer MST after RT for treatment of nasal LSA (Fu J Vet Med Sci 2016)

A

ki67 - >40%

22
Q

Expression of which cox isoform is found in normal nasal tissue vs. nasal carcinoma? (Kleiter VRU 2004, borzacchiello j comp path 2004)

A

cox 1 - normal tissue, rare in tumors

cox 2 strongly expressed in all tumors

23
Q

What was found to be prognostic in dogs with untreated nasal tumors? What was the MST for untreated nasal tumors in dogs? (Rassnick JAVMA 2006)

A

epistaxis (88d vs. 224d) - not necessarily consistent with more current lit

overall MST 95d (88 w/ epistaxis vs. 224d w/o)

24
Q

Describe the six factors assessed for CT staging of nasal tumors and what are the stages (J Vet Med Sci 2008)

A
  1. tumor invasion to bilateral nasal/paranasal sinus clear on enhanced CT
  2. nasal bone destruction + tumor grossly found
  3. involvement of oral cavity with destruction of hard palate
  4. orbital involvement + eyeball compression
  5. frontal sinus involvement
  6. ​brain involvement

Stage 1 = 0/6, stage 2 = 1 finding (only 1-5), stage 3 = 2 findings (only 1-5) stage IV = any with criteria 6

25
Q

What are the modified adams stages for nasal carcinomas VRU 2009

A

1 confined to one nasal passage

2 any bony involvment (beyond turbinates)

3 = orbit or nasopharyngeal or SQ mass

4 = lysis of cribriform

26
Q

What RT protocols are the most appropriate for treatment of nasal sarcomas in dogs? (Sones VRU 2012)

A

Curative intent RT - daily 641d, MWF = 347d, weekly = 344d (MSTs)

27
Q

When treated with RT, which type of nasal sarcoma in dogs had the best MST? (sones VRU 2012)

A

OSA (624d), Chondro (463d), fibro (379d), undifferentiated (344d)

28
Q

What was the MST for dogs with intermediate to high grade LSA treated with RT +/- chemo vs. RT alone? (George VRU 2016)

A

RT +/- chemo = 455d

chemo alone = 157d

29
Q

What was the MST for dogs treated with RT +/- chemo (George VRU 2016)

A

823d

30
Q

What IHC are feline pulmonary carcinomas positive for in >80% of cases? (D’Costa Vet Path 2012)

A

Surfactant protein A

thyroid transcritption factor 1 (TTF1)

31
Q

What is associated with metastatic potential for feline pulmonary tumors? (D’Costa Vet Path 2012)

A

>2cm

Oncology Boards (26 decks)

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