Stroke Case Drugs

Question 1

Heparin

Answer 1

binds to inactive antithrombin
conformational change so it can bind to thrombin
blocks thrombin from being able to convert fibrinogen to fibrin
prevent further blood clotting

Anticoagulant

Question 2

Warfarin

Answer 2

inhibits vitamin k reductase in liver cells
decreased production of vitamin k
stops conversion of glutamic acid to gamma carboxyglutamic acid
less production of clotting factors

Anticoagulant

Question 3

Dabigatran, apixaban and rivaroxaban

Answer 3

competitive direct thrombin inhibitor, stop production of thrombin mediated clotting factors

Anticoagulant

Question 4

Aspirin

Answer 4

irreversibly inhibits the cox1/cox2 enzymes
stops the conversion of arachidonic acid into prostaglandin H2 and then thromboxane A2
stops platelet aggregation
stops blood clots forming

Antiplatelet

Question 5

Clopidogrel

Answer 5

irreversibly inhibits receptor on platelet cell membrane
deactivating effect of G protein on membrane
activation of adenylate cyclase
restores production of cAMP in cell
decreased activation of fibrinogen-binding protein
less platelet aggregation

Antiplatelet