Pernicious Anaemia Case Drugs

Question 1

Hydroxocobalamin

Answer 1

Hydroxocobalamin is a man-made injectable form ofvitamin B12 used to treat low levels (deficiency) of this vitamin
Vitamin B12 helps your body usefat and carbohydrates for energy and make new protein.
It is also important for normalblood, cells, and nerves.

DOSAGE:Initially 1 mg 3 times a week for 2 weeks, then 1 mg every 2–3 months
This quickly builds up the body’s store of vitamin B12 and it is stored in the liver.
Once a store of vitamin B12 has built up, this can supply the body’s needs for several months. An injection is then only usually needed every two to three months to top up the supply.

Vitamin B12replacement usually administered intramuscularly
Usually absorbed via ileum in the presence of intrinsic factor
Injecting hydroxocobalamin intramuscularly results in higher bioavailability compared to oral administration