Pneumothorax Case Drugs Flashcards
Anaesthetic effect table
General anaesthesia mechanism
it can be hypothesized that anaesthesia results from either enhanced inhibitory transmission or reduced excitatory transmission. Two main targets include; GABAA receptors and N-methyl-D-aspartate (NMDA) glutamate receptors. On γ-aminobutyric acid (GABA) binding to GABAA receptors an influx of Cl− ions results to produce a hyperpolarization. With the exception of ketamine, xenon and nitrous oxide, all anaesthetic agents potentiate (increase the power of) the inhibitory function of GABA-mediated conductance. On binding of the main excitatory transmitter glutamate, NMDA receptors gate an influx of Ca2+ and Na+. Ketamine, xenon and nitrous oxide inhibit this ion movement to depress excitatory transmission.
