DVT And PE Case Drugs

Question 1

Dabigatran

Answer 1

Anticoagulant

Question 2

Rivaroxaban

Answer 2

Anticoagulant

Question 3

Warfarin

Answer 3

1. Warfarin blocks Vit K epoxide reductase
   ➢Depletes Vitamin K
2. Vitamin K is co-factor for PTM of glutamate
   ➢↓Vit K → dysfunctional Factors II, VII, IX, X
3. Ca2+
   -dependent binding of Factors II, VII, IX, X to platelet phosphatidylserine (PS) is reduced
   ➢↓thrombin (IIa) formation
4. No thrombin → No fibrin → No coagulation

Question 4

Alteplase

Answer 4

Question 5

Antifibrinolytics

Answer 5

Question 6

Desmopressin

Answer 6

Question 7

Naproxen

Answer 7

Question 8

LMW heparin

Answer 8