Step 1 Heme review

Question 1

Multiple myeloma

CRAB

caused by malignant transformation of ____

Answer 1

Ca elevated
renal impairment
anemia
bone fracture/pain

post germinal center plasma cells

Question 2

Hb electrophoresis

FSA
F
FA
FS
FAS

Answer 2

Hb S/B thalassemia disease
B thalassemia
normal
sickle cell disease
sickle trait

Question 3

ALL

usual age
clincal- __ sx, __ pain, __/__

Labs- __, variable __, atypical ___, ___

smear shows

Answer 3

<18
anemia, bone, HSM, LAD

anemia, leukocytes, lymphs, thrombocytopenia

lymphoblasts

Question 4

CLL

age range
usually __, may have ___

labs; normal __, __, __ > 5000, normal ___

smear shows __ aka ___

Answer 4

50-80yrs
asx, Splenomegaly

Hb, leukocytosis, lymphs, platelets

atypical lymphs, smudge cells

Question 5

AML

ages can be __ or __

clincial: __ sx, spontaneous __, __/__

Labs: __, __ and __, and __

smear: __ and ___

Answer 5

early childhood, late adulthood

anemia, bleed, petechiae, purpura

anemia, leukopenia, neutropenia, thromboytopenia

myeloblasts, auer rods

Question 6

CML

age range
clinical: __ sx, __

labs: mild __, __ >100,000, immature __, normal __
smear: immature ___, inc __/__

Answer 6

50-80yrs
anemia, splenomegaly

anemia, leukocytosis, myeloid, platelets

myeloid, eos/basophils

Question 7

ABO incompatability

mother blood type __
kid is usually type __ or __

baby has ___, __

Answer 7

O
A or B

jaundice, scleral icterus

Question 8

von willebrand disease most common cause of __

think esp in __ with heavy __

labs
PT
PTT
Platelet

Answer 8

heavy bleeding

women, menses

normal
normal
normal

Question 9

bacterial infection, LAD, associated with farm/animals

most common cause is

can lead to
gram negative __

Answer 9

bartonella henslae

bacillary angiomatosis
rod

Question 10

older woman, new history of bleeding disorder

dx test

Answer 10

bone marrow biopsy